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Tissue Engineering Based on the Importance of Collaboration Between Clinicians and Basic Scientists Regarding Mesenchymal Stromal Cells

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Book cover Adult and Embryonic Stem Cells

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Tissue engineering is an interdisciplinary field that applies the principles of biology and engineering to developing tissue substitutes to restore, maintain, or improve the function of diseased or damaged human tissues. Autologous mesenchymal stromal cells (MSCs) are good candidates for tissue engineering and regenerative medicine in that they can replace damaged tissues in the human body owing to their self-renewal, plasticity, engraftment, and homing capacity. MSCs can easily differentiate into adipocytes, osteoblasts, and fibroblasts using various transcription factors and hormones. For cell treatments, nanotechnological scaffolds in various structures are needed for differentiation of stem cells. Biodegradable polymeric constructs for bone tissue engineering, are three-dimensional structures that allow bone cells to attach and reproduce on them. Because of biodegradability properties, they are not permanent in the body and are degraded slowly while bone cells are reproducing. Thus, bone cells replace the scaffold in time, which means healing of the defective site.

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Authors and Affiliations

  1. Ege Üniversity Cancer Research Center (consultant), İzmir, Turkey

    Aysel Yurtsever M.D.

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  1. Aysel Yurtsever M.D.
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Correspondence to Aysel Yurtsever M.D. .

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  1. Smyth Rd 501, Ottawa, K1H 8L6, Canada

    Kursad Turksen

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Yurtsever, A. (2012). Tissue Engineering Based on the Importance of Collaboration Between Clinicians and Basic Scientists Regarding Mesenchymal Stromal Cells. In: Turksen, K. (eds) Adult and Embryonic Stem Cells. Stem Cell Biology and Regenerative Medicine. Humana Press. https://doi.org/10.1007/978-1-61779-630-2_7

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