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Role of Malondialdehyde in the Age-Related Macular Degeneration

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Book cover Studies on Retinal and Choroidal Disorders

Abstract

The pathogenesis of age-related macular degeneration (AMD) is not clear. The most important risk factors for developing AMD are age, race, and smoking. Genetics, inflammation, and oxidative stress have all been suggested to play a role. The retina is rich in oxygen, free radicals, polyunsaturated fatty acid, and photoactive substances such as lipofuscin, and is exposed to high levels of visible irradiation. Aging is associated with increased oxidative injury. Lipid peroxidation and lipofuscin formation is also increased with aging. Malondialdehyde (MDA) is a product of lipid peroxidation and can be used as a biomarker for oxidative stress. In this chapter, we summarize the available evidence of oxidative stress in the pathogenesis of AMD. In addition, we have demonstrated that high levels of MDA were present in patients with AMD compared to patients without AMD. This suggests that lipid peroxidation-induced oxidative stress may play a role in the pathogenesis of AMD.

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Authors and Affiliations

  1. Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX, 75390-9057, USA

    Hao Wang, Biren Zhao, Ivan Vrcek, John M. Johnston & Yu-Guang He

Authors
  1. Hao Wang
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  2. Biren Zhao
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  3. Ivan Vrcek
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  4. John M. Johnston
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  5. Yu-Guang He
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Corresponding author

Correspondence to Yu-Guang He .

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Editors and Affiliations

  1. W. Southwinds Blvd. 1250, Vero Beach, 32963, Florida, USA

    Robert D. Stratton

  2. Department of Ophthalmology, University of Florida, SW Archer Road 1600, Gainesville, 32610, Florida, USA

    William W. Hauswirth

  3. Molecular and Integrative Physiology, Ophthalmology and Visual Sciences, Kellogg Eye Center, Wall Street 1000, Ann Arbor, 17033-2390, Michigan, USA

    Thomas W. Gardner

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Wang, H., Zhao, B., Vrcek, I., Johnston, J.M., He, YG. (2012). Role of Malondialdehyde in the Age-Related Macular Degeneration. In: Stratton, R., Hauswirth, W., Gardner, T. (eds) Studies on Retinal and Choroidal Disorders. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press. https://doi.org/10.1007/978-1-61779-606-7_4

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