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Deposition and Oxidation of Lipoproteins in Bruch’s Membrane and Choriocapillaris Are “Age-Related” Risk Factors with Implications in Age-Related Macular Degeneration

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Studies on Retinal and Choroidal Disorders

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Abstract

This chapter reviews the deposition and oxidation of LDL in Bruch’s membrane (BrM), the retinal pigment epithelium (RPE), and the choriocapillaris (CH) and the potential consequences of this deposition in relation to age-related macular degeneration (AMD). Lipid deposition and oxidation are age-related effects that when considered systemically play an important role in most if not all age-related diseases. Oxidized lipid deposits are found throughout the vascular system where they can initiate chronic inflammatory responses that cause cellular stress and loss of function. Aging is a complex multifactorial process that sets the stage for genetic and environmental factors that initiate the pathogenesis of AMD and other age-related diseases.

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Authors and Affiliations

  1. Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, Building 6, 136, 6 Center Dr, Bethesda, MD, 20892, USA

    Ignacio R. Rodriguez

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  1. Ignacio R. Rodriguez
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Correspondence to Ignacio R. Rodriguez .

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  1. W. Southwinds Blvd. 1250, Vero Beach, 32963, Florida, USA

    Robert D. Stratton

  2. Department of Ophthalmology, University of Florida, SW Archer Road 1600, Gainesville, 32610, Florida, USA

    William W. Hauswirth

  3. Molecular and Integrative Physiology, Ophthalmology and Visual Sciences, Kellogg Eye Center, Wall Street 1000, Ann Arbor, 17033-2390, Michigan, USA

    Thomas W. Gardner

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Rodriguez, I.R. (2012). Deposition and Oxidation of Lipoproteins in Bruch’s Membrane and Choriocapillaris Are “Age-Related” Risk Factors with Implications in Age-Related Macular Degeneration. In: Stratton, R., Hauswirth, W., Gardner, T. (eds) Studies on Retinal and Choroidal Disorders. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press. https://doi.org/10.1007/978-1-61779-606-7_15

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