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Bone Marrow–Derived Cells as Treatment Vehicles in the Central Nervous System

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Regenerative Therapy Using Blood-Derived Stem Cells

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Substantial research has focused on the potential for bone marrow–derived cells (BMDCs) to function as vehicles to transport pharmaceuticals into the diseased central nervous system (CNS). By employing bone marrow–chimeric models, investigators have determined that BMDCs retain their hematopoietic identity within the CNS with a majority of cells acquiring macrophage phenotypes. Although the use of irradiation in creating bone marrow chimeras is believed to be necessary for the engraftment of BMDCs within the CNS, further investigations into alternative conditioning regimens will improve the clinical potential for this treatment modality.

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Author information

Authors and Affiliations

  1. Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada

    Coral-Ann B. Lewis

  2. Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada

    Fabio M. Rossi

  3. Division of Neurology, Department of Medicine, Neuromuscular Disease Unit, VHHSC, Vancouver, BC, Canada

    Charles Krieger

Authors
  1. Coral-Ann B. Lewis
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  2. Fabio M. Rossi
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  3. Charles Krieger
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Corresponding author

Correspondence to Charles Krieger .

Editor information

Editors and Affiliations

  1. Ottawa Hospital Research Institute, Parkdale Ave 725, Ottawa, K1Y4E9, Ontario, Canada

    David S. Allan

  2. , Center for Medical Research (ZMF), Medical University of Graz, Stiftingtalstraße 24, Graz, A - 8010, Austria

    Dirk Strunk

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Lewis, CA.B., Rossi, F.M., Krieger, C. (2012). Bone Marrow–Derived Cells as Treatment Vehicles in the Central Nervous System. In: Allan, D., Strunk, D. (eds) Regenerative Therapy Using Blood-Derived Stem Cells. Stem Cell Biology and Regenerative Medicine. Humana Press. https://doi.org/10.1007/978-1-61779-471-1_9

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