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Oxidative Stress in Cancer Biology and Therapy pp 407–425Cite as

Antioxidants and Inhibition of Cisplatin-Induced Kidney Injury: Role of Mitochondria

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Abstract

Since its approval by the FDA in 1979, cisplatin (CP) has been widely employed in the treatment of several malignancies, including both solid and hematological tumors. Kidneys are particularly susceptible to the action of cisplatin, and despite the preventive measures currently applied, nephrotoxicity remains the most important dose-limiting factor in cisplatin chemotherapy. It has been suggested that mitochondrial oxidative stress and unbalance of the redox status play a key role in the mechanism of CP-induced nephrotoxicity. Therefore, as an attempt to counteract the renal damage associated with cisplatin chemotherapy, many antioxidants, both synthetic and natural, endogenous and exogenous, with distinct mechanisms of action, including free-radical scavengers, sulfhydryl donors and iron chelators, have had their potential as protective agents evaluated. Results are encouraging in the great majority of the studies and many different antioxidants have been presented as potential candidates to the adjuvant protective therapy. The most promising compounds, the conflicting findings and the remaining concerns are thoroughly discussed in this chapter.

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Authors and Affiliations

  1. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, USP, Avenida do Café s/n, Ribeirão Preto, SP, 14040-903, Brazil

    Neife Ap. Guinaim dos Santos PhD & Antonio Cardozo dos Santos PhD

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  1. Neife Ap. Guinaim dos Santos PhD
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  2. Antonio Cardozo dos Santos PhD
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Correspondence to Antonio Cardozo dos Santos PhD .

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Editors and Affiliations

  1. Free Radical & Radiation Biology, Graduate Program, University of Iowa, Iowa City, 52242, Iowa, USA

    Douglas R. Spitz

  2. Duluth Clinic, Radiation Oncology, University of Minnesota, East 3rd Street 400, Duluth, 55805, Minnesota, USA

    Kenneth J. Dornfeld

  3. James H. Quillen College of Medicine, Internal Medicine, East Tennessee State University, Johnson City, 37614, Tennessee, USA

    Koyamangalath Krishnan

  4. Radiation Oncology, Cancer Biology and Pediatrics, Vanderbilt Medical School, 21st Ave. 1161, Nashville, 37232, Tennessee, USA

    David Gius

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dos Santos, N.A.G., dos Santos, A.C. (2012). Antioxidants and Inhibition of Cisplatin-Induced Kidney Injury: Role of Mitochondria. In: Spitz, D., Dornfeld, K., Krishnan, K., Gius, D. (eds) Oxidative Stress in Cancer Biology and Therapy. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-397-4_20

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