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Persistent Trophoblastic Neoplasia

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Part of the Current Clinical Pathology book series (CCPATH)

Abstract

In 2002, FIGO introduced the term “persistent trophoblastic neoplasia” or gestational trophoblastic neoplasia (GTN) to include persistent mole, invasive mole, metastatic mole, choriocarcinoma, and trophoblastic tumors under one clinical term for management purposes (Int J Gynecol Cancer 11(1):73–77, 2001), because all patients with such a diagnosis require chemotherapy (N Engl J Med 360(16):1639–1645, 2009). The criteria include serial hCG does not return to normal after evacuation (4 or more hCG levels that show a plateau for more than 3 weeks; an increase of 10% or more in three or more measurements for at least 2 weeks or persistence of detectable hCG 6 months after evacuation; evidence of metastasis; and a tissue diagnosis of gestational choriocarcinoma). This is a rather important development resulting in a clinical treatment decision based on clinical and serum hCG marker evaluation without a need of tissue diagnosis. Thereafter, histological diagnosis under the sequelae after a molar pregnancy in an individual patient has become uncertain since the introduction of GTN.

Keywords

Persistent trophoblastic neoplasia Differential diagnosis 

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of PathologyYale University School of MedicineNew HavenUSA

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