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Molecular Diagnosis of Gestational Trophoblastic Disease

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Part of the Current Clinical Pathology book series (CCPATH)

Abstract

Among gestational trophoblastic disorders, hydatidiform moles are the most common in the daily practice of gynecological pathology and frequently diagnostically challenging. While histological diagnosis of well-developed complete hydatidiform mole is generally reliable (see Chaps. 5 and 6), an early evacuated complete mole often presents with minimal histological abnormalities and is easily mistaken as a hydropic abortus or a normal pregnancy by both clinicians and pathologists (Adv Anat Pathol 12(3):116-25, 2005). Partial hydatidiform moles have been proven the most diagnostically difficult. At present time and even with available ancillary studies, pathologists cannot reliably classify a partial mole from its many mimics with both under- and over-diagnosis in a significant percentage of the cases.

Keywords

Molecular diagnosis of GTD Tissue genotyping STR 

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© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of PathologyYale University School of MedicineNew HavenUSA

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