Use of Large Animal and Nonhuman Primate Models for Cell Therapy and Tissue Engineering

  • Alice F. TarantalEmail author
  • Karina H. Nakayama
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)


The intent of this chapter is to highlight the contributions of large animal models including pigs, sheep, goats, dogs, and nonhuman primates. These species are crucial for clinical translation of new cell and tissue engineering approaches for the treatment of human diseases. Choice of species, age, and model validation are necessary to ensure outcomes are predictive, and recapitulate human development, anatomy, physiology, and disease. The overriding objective is to select a model that can reliably assess the safety and efficacy of new therapies beyond the discovery phase and to obtain results that can be translated to clinical trials in children and adults.


Spinal Cord Injury Nonhuman Primate Vascular Graft Large Animal Model PLGA Scaffold 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Anterior cruciate ligament




Computed tomography


Clinical and Translational Science Award


Deoxycholic acid


Endothelial colony forming cell


Extracellular matrix


End-stage renal disease




Myocardial infarction


Mesenchymal stem cells


National Institutes of Health


Peripheral arterial disease




Platelet-derived growth factor


Polyglycolic acid


Poly(lactide-co-glycolic acid)


Poly-l-lactide acid




Retinal pigmented epithelium


Small intestinal submucosa


Tricalcium phosphate


Vascular endothelial growth factor



Dr. A.F. Tarantal is Staff Scientist and Unit Leader at the California National Primate Research Center (NIH RR00169), and directs the NHLBI Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases (NIH HL85794), and the Translational and Pilot Programs in the UC Davis Clinical and Translational Science Center (CTSC) (NIH RR024146). Ms. K.H. Nakayama is a predoctoral scholar in the UC Davis Stem Cell Training Program (CIRM T1-00006 and TG2-01163) and a former CTSC T32 trainee.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Departments of Pediatrics, Cell Biology and Human Anatomy, School of Medicine, UC Davis Clinical and Translational Science Center, California National Primate Research CenterUniversity of CaliforniaDavisUSA

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