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Hollow Organ Engineering

  • Anthony AtalaEmail author
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

Applications of regenerative medicine technology may offer novel therapies for patients with injuries, end-stage organ failure, or other clinical problems. Currently, patients suffering from diseased and injured organs can be treated with transplanted organs. However, there is a severe shortage of donor organs that is worsening yearly as the population ages and new cases of organ failure increase. Scientists in the field of regenerative medicine and tissue engineering are now applying the principles of cell transplantation, material science, and bioengineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. In particular, efforts to engineer hollow organs, such as the urinary bladder, urethra, and vagina, have been particularly successful to date. Some therapies arising from these tissue engineering endeavors have already entered the clinical setting successfully, indicating the promise regenerative medicine holds for the future.

Keywords

Regenerative Medicine Adult Stem Cell Urothelial Cell Composite Scaffold Bladder Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

AFPS

Amniotic-fluid and placental-derived stem

ECM

Extracellular matrix

hESC

Human embryonic stem cell

iPSC

Induced pluripotent stem cell

PCL

Polycaprolactone

PGA

Polyglycolic acid

PLA

Polylactic acid

PLGA

Poly (lactic-co-glycolic acid)

SCNT

Somatic cell nuclear transfer

SIS

Small intestinal submucosa

Notes

Acknowledgment

The author would like to thank Dr. Jennifer Olson for editorial assistance with this manuscript.

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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Wake Forest Institute for Regenerative MedicineWake Forest University School of MedicineWinston-SalemUSA

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