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Skeletal Muscle Engineering: The Need for a Suitable Niche

  • Frédéric Trensz
  • Anthony Scimè
  • Guillaume GrenierEmail author
Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

There are currently no curative treatments available for people suffering from one of the many prevalent disease- and trauma-related muscle myopathies. One approach to ameliorate these conditions relies on the cell-based transplantation of myogenic stem cells or, more optimistically, the transfer of engineered skeletal muscle tissue. To date, clinical trials with myogenic stem cell transplantation have met with only modest success while engineered muscle tissue transplantation is at its earliest stages of development. The many studies on muscle tissue engineering underscore the importance of the myogenic stem cell niche that plays a pivotal role in transplantation success. More work is required to determine the components of the niche required for improving the integration and function of transplanted cells and engineered tissues in host muscle.

Keywords

Satellite Cell Basal Lamina Myogenic Cell Skeletal Muscle Tissue Myogenic Potential 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

bFGF

Basic fibroblast growth factor

DMD

Duchenne muscular dystrophy

ECM

Extracellular matrix

EGF

Epidermal growth factor

HGF

Hepatocyte growth factor

IGF1

Insulin-like growth factor-1

PEG

Poly(ethylene glycol)

PGA

Polyglycolic acid

PLLA

Poly-l-lactic acid

VEGF

Vascular endothelial growth factor

WNT

Wingless integration site

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Frédéric Trensz
    • 1
  • Anthony Scimè
    • 2
  • Guillaume Grenier
    • 3
    • 4
    Email author
  1. 1.Étienne-Lebel Clinical Research CenterUniversité de SherbrookeSherbrookeCanada
  2. 2.Muscle Health Research CentreYork UniversityTorontoCanada
  3. 3.Étienne-Lebel Clinical Research CenterUniversité de SherbrookeSherbrookeCanada
  4. 4.Department of Orthopedic SurgeryUniversité de SherbrookeSherbrookeCanada

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