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Hematopoietic Stem Cell Transplantation: Reflections on Yesterday and Thoughts for Tomorrow

  • Andrew D. LeavittEmail author
Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

Biomedical science is entering a new era with exciting prospects for using cellular therapy to treat a wide spectrum of human diseases from nerve injury to diabetes, myocardial infarction, and more. Hematopoietic stem cell (HSC) transplantation has been used to treat patients for nearly half a century. The experiences and lessons learned over those 50 years are both informative and encouraging. This chapter distills the history of HSC transplantation to provide an orientation to the past that can be used to more wisely navigate the future of cell therapy. The details presented help the reader appreciate that developing novel cell therapy can be a struggle and that chance will likely continue to play a role in future success. However, it also becomes apparent that attention to fundamental details, such as choice of cell type or types, where to obtain the cells, how to handle and process the cells, how to prepare and select patients, how to evaluate success and failure, and how to organize the biomedical community to serve the good of patients, are all critical for new cell therapy to become a reality.

Keywords

Hematopoietic Stem Cell Hematopoietic Stem Cell Transplantation Aplastic Anemia Total Body Irradiation Stem Cell Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

BMT

Bone marrow transplantation

GVHD

Graft-versus-host disease

GVL

Graft-versus-leukemia

HLA

Human lymphocyte antigen

HSCs

Hematopoietic stem cells

PBSCs

Peripheral blood stem cells

UCB

Umbilical cord blood

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Departments of Laboratory Medicine and Medicine, UCSF Adult Blood and Marrow Transplant LaboratoryUniversity of CaliforniaSan FranciscoUSA

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