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Adhesive Interactions of Tissue Cells with the Extracellular Matrix

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Adhesive Interactions in Normal and Transformed Cells

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Abstract

Adhesive interactions of cells with the extracellular matrix start soon after they ­settle on the matrix from suspended state. The matrix-attached spherical cells begin to spread and gradually reach high degree of flattening. The cell spreading process includes defined consecutive changes both in the cell shape and in the cell surface relief. Oncogenic transformation results in a deficient cell spreading. Adhesive interactions include intracellular signal transduction pathways in the cells. The signaling pathways are triggered by the extracellular stimulatory molecules (ligands) following their binding to different types of specialized cell surface receptors. In particular, integrin receptors, which are components of focal adhesions and play a key role in cell-matrix attachment, also function as signal transducers. Different integrin-mediated and growth factor receptor-mediated signaling pathways determine and control cell morphology, proliferation, survival, and migration. The oncogenic transformation results in the weakening of integrin-mediated cell-matrix adhesion and induces serious alterations in the integrin-mediated and growth factor receptor-mediated signaling pathways. The consequences of these alterations are the “anchorage independence” (substratum independence of cell proliferation), permanent mitogenic activation, loss of cell detachment-induced apoptosis (anoikis), and high migratory activity of transformed cells.

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  1. Research Center of the Russian Academy of Medical Sciences, Moscow, Russia

    Yury A. Rovensky M.D., Ph.D., D.Sci (Former Leading Researcher at Cancer)

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Rovensky, Y.A. (2011). Adhesive Interactions of Tissue Cells with the Extracellular Matrix. In: Adhesive Interactions in Normal and Transformed Cells. Humana Press. https://doi.org/10.1007/978-1-61779-304-2_5

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