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Cell Therapy for Cardiovascular Disorders

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Applications of Biotechnology in Cardiovascular Therapeutics

Abstract

New cell-based therapeutic strategies are being developed in response to the shortcomings of available treatments for heart disease. Potential repair by cell grafting or mobilizing endogenous cells holds particular attraction in heart disease, where the meager capacity for cardiomyocyte proliferation likely contributes to the irreversibility of heart failure. Cell therapy approaches include attempts to reinitiate cardiomyocyte proliferation in the adult, conversion of fibroblasts to contractile myocytes, conversion of bone marrow (BM) stem cells into cardiomyocytes, and transplantation of myocytes or other cells into injured myocardium. Basics and techniques of cell therapy have been described in a special report on this topic (Jain 2011). Applications in cardiovascular disorders will be described in this chapter including methods of delivery of cells.

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  1. Jain PharmaBiotech, Blaesiring 7, Basel, 4057, Switzerland

    Kewal K. Jain

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Jain, K.K. (2011). Cell Therapy for Cardiovascular Disorders. In: Applications of Biotechnology in Cardiovascular Therapeutics. Humana Press. https://doi.org/10.1007/978-1-61779-240-3_7

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