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Inherent Nuclear Reprogramming in Mammalian Embryos

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Nuclear Reprogramming and Stem Cells

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

In the current literature, the term “nuclear reprogramming” is defined as either the switch of the gene expression state from one cell type to another or the change of a differentiated, specialized cell into a developmentally more ­primitive but more pluripotent state. Experimentally, nuclear reprogramming can be achieved by somatic cell nuclear transfer (SCNT) into oocytes, by cell fusion, or by introduction of specific transcription factors into a cell. The epigenome of the target cell becomes altered and a gain of developmental potential ensues. During embryogenesis, nuclear reprogramming is achieved inherently through complex epigenetic processes. Here we focus on the natural, forward process of differentiation in the developing mouse embryo and discuss the key epigenetic reprogramming events involved.

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Authors and Affiliations

  1. Mammalian Development Group, Agency for Science, Technology and Research, Institute of Medical Biology, Singapore, Singapore

    Ai Khim Lim, Barbara B. Knowles & Daniel M. Messerschmidt

  2. Germline Biology Laboratory, Temasek Life Sciences Laboratory, Department of Biological Sciences, The National University of Singapore, Singapore, Singapore

    Toshie Kai

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  1. Ai Khim Lim
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  2. Barbara B. Knowles
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  3. Toshie Kai
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  4. Daniel M. Messerschmidt
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Correspondence to Daniel M. Messerschmidt .

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Editors and Affiliations

  1. Leeds Institute of Genetics,, Health & Therapeutics, University of Leeds, Leeds, LS2 9JT, United Kingdom

    Justin Ainscough

  2. Inst. Frontier Medical Sciences, Kyoto University, Kawahara-cho 53, Kyoto, 606-8507, Japan

    Shinya Yamanaka

  3. Inst. Frontier Medical Sciences, Kyoto University, Kawahara-cho 53, Kyoto, 606-8507, Japan

    Takashi Tada

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Lim, A.K., Knowles, B.B., Kai, T., Messerschmidt, D.M. (2011). Inherent Nuclear Reprogramming in Mammalian Embryos. In: Ainscough, J., Yamanaka, S., Tada, T. (eds) Nuclear Reprogramming and Stem Cells. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-225-0_3

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