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Regenerating Function In Vivo with Myocytes Derived from Embryonic Stem Cells

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Regenerating the Heart

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Myocardial infarction, or heart attack, is a principal cause of congestive heart failure and adult morbidity and mortality in the western world. Since the adult myocardium lacks the inherent ability to repair itself following ischemic injury, a number of exogenous cell sources with differing cardiomyogenic potential have been investigated for the restoration of infarcted myocardium. To this end, the ability of embryonic-stem-cell-derived cardiomyocytes (ESC-CMs) to successfully engraft within host myocardium, fully differentiate to a mature cardiomyogenic phenotype, and electromechanically couple with host cardiomyocytes upon transplantation has been a subject of much inquiry in recent years. Overall, these studies demonstrate that the use of ESC-CMs alone or in conjunction with a biodegradable scaffold serves as a novel route to restore cardiomyocytes to the heart and thereby facilitate myocardial repair and functional regeneration.

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Authors and Affiliations

  1. The Wallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University, Petit Institute for Bioengineering and Bioscience, Atlanta, GA, USA

    Todd C. McDevitt

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  1. Priya R. Baraniak
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  2. Todd C. McDevitt
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Correspondence to Todd C. McDevitt .

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Editors and Affiliations

  1. Health Sciences Center, Dept. Physiology & Biophysics, Stony Brook University, Stony Brook, 11794-8661, New York, USA

    Ira S. Cohen

  2. Worcester Polytechnic Institute, Institute Rd. 100, Worcester, 01609-2280, Massachusetts, USA

    Glenn R. Gaudette

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Baraniak, P.R., McDevitt, T.C. (2011). Regenerating Function In Vivo with Myocytes Derived from Embryonic Stem Cells. In: Cohen, I., Gaudette, G. (eds) Regenerating the Heart. Stem Cell Biology and Regenerative Medicine. Humana Press. https://doi.org/10.1007/978-1-61779-021-8_3

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