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Rationale and Historical Perspective of Intraoperative Irradiation

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Intraoperative Irradiation

Part of the book series: Current Clinical Oncology ((CCO))

Abstract

Most of the major advances in clinical applications of radiation therapy in the treatment of cancer have been due to differences in dose distribution between tumor and dose-limiting normal tissue. For most tumor types, the likelihood of obtaining local tumor control improves if irradiation doses delivered to the tumor mass can be safely increased. However, in many clinical situations, the dose which can be delivered safely to the tumor volume is limited by the normal tissues which are in close proximity to the tumor volume.

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Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Mayo Clinic College of Medicine and Mayo Clinic Arizona, Scottsdale, AZ, USA

    Leonard L. Gunderson

  2. Department of Oncology, Hospital Gregorio Maranón, Madrid, Spain

    Felipe A. Calvo

  3. Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA

    Christopher G. Willett

  4. Department of Radiation Oncology, Continuum Cancer Centers of New York, Beth Israel Medical Center, St Luke’s and Rooseuelt Hospitals, Alberts Einstein College of Medicine, New York, NY, USA

    Louis B. Harrison

Authors
  1. Leonard L. Gunderson
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  2. Felipe A. Calvo
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  3. Christopher G. Willett
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  4. Louis B. Harrison
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Corresponding author

Correspondence to Leonard L. Gunderson .

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Mayo Clinic, East Shea Blvd 13400, Scottsdale, 85259, Arizona, USA

    Leonard L. Gunderson

  2. Dept. Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA

    Christopher G. Willett

  3. Gregorio Marañón, Depto. Radiación de Oncología, Hospital General Universitario, C/ Dr. Esquerdo 46, Madrid, 28007, Spain

    Felipe A. Calvo

  4. Albert Einstein College of Medicine, Radiation Oncology, Beth Israel Medical Center, Union Square East 10, New York, 10003, New York, USA

    Louis B. Harrison

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Gunderson, L.L., Calvo, F.A., Willett, C.G., Harrison, L.B. (2011). Rationale and Historical Perspective of Intraoperative Irradiation. In: Gunderson, L., Willett, C., Calvo, F., Harrison, L. (eds) Intraoperative Irradiation. Current Clinical Oncology. Humana Press. https://doi.org/10.1007/978-1-61779-015-7_1

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