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The Opiate Receptors pp 389–405Cite as

Opioid Receptor Trafficking

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Part of the book series: The Receptors ((REC))

Abstract

The functioning of opioid receptors involves a wide range of processes. Their association with G-proteins is clearly one of the most important. However, receptor trafficking also plays a crucial role in their activation, inactivation and desensitization. This review will attempt to summarize the receptors from their synthesis to their eventual proteolytic elimination.

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Acknowledgements

Many investigators have made major contributions to this field; I regret that only a limited subset of important papers could be cited in the present review. I am personally indebted to my mentors, colleagues, and trainees, whose intelligence and energy have driven the field forward and made working in it highly enjoyable. I gratefully acknowledge the National Institutes of Health, and particularly the National Institute on Drug Abuse, for critical financial support.

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  1. Departments of Psychiatry and Cellular and Molecular Pharmacology, UCSF School of Medicine, San Francisco, CA, USA

    Mark von Zastrow

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  1. Mark von Zastrow
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Correspondence to Mark von Zastrow .

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  1. , Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, 10065, New York, USA

    Gavril W. Pasternak

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von Zastrow, M. (2011). Opioid Receptor Trafficking. In: Pasternak, G. (eds) The Opiate Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-993-2_14

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