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The Making of the 5-HT2C Receptor

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5-HT2C Receptors in the Pathophysiology of CNS Disease

Part of the book series: The Receptors ((REC,volume 22))

Abstract

This chapter is a personal account of how the 5-HT2C receptor was discovered and characterized more than 25 years ago. 5-HT2C receptors, initially called 5-HT1C, were found while studying the distribution in the brain of binding sites for the compound mesulergine, a ligand with serotonergic and dopaminergic properties. The strong labeling to choroid plexus revealed a site with pharmacological properties different from the known 5-HT receptors at that time. In the following 10 years, 5-HT1C (later 5-HT2C) was extensively characterized pharmacologically, anatomically, and functionally, leading finally to the cloning of its gene. Since then, intense research has been dedicated to the search a therapeutic use for modulators of these receptors.

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Authors and Affiliations

  1. BrainCo Biopharma, Parque Tecnológico de Vizcaya, Edificio 801, 48160, Derio (Bilbao), Spain

    Jose M. Palacios

Authors
  1. Jose M. Palacios
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  2. Angel Pazos
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  3. Daniel Hoyer
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Corresponding author

Correspondence to Jose M. Palacios .

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Editors and Affiliations

  1. , Department of Physiology and Biochemistr, University of Malta, Msida, Malta, MSD 2080, Italy

    Giuseppe Di Giovanni

  2. Centro di Ricerche Farmacologiche e, Biomediche, Consorzio Mario Negri Sud, Via Nazionale 8, Santa Maria Imbaro, 66030, Chieti, Italy

    Ennio Esposito

  3. Centro di Ricerche Farmacologiche e, Biomediche, Consorzio Mario Negri Sud, Via Nazionale 8, Santa Maria Imbaro, 66030, Chieti, Italy

    Vincenzo Di Matteo

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Palacios, J.M., Pazos, A., Hoyer, D. (2011). The Making of the 5-HT2C Receptor. In: Di Giovanni, G., Esposito, E., Di Matteo, V. (eds) 5-HT2C Receptors in the Pathophysiology of CNS Disease. The Receptors, vol 22. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-941-3_1

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