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Cystectomy for Nonmuscle-Invasive Bladder Cancer

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Bladder Tumors:

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Nonmuscle-invasive bladder tumors represent a heterogeneous group of cancers that include those that are generally papillary in nature and limited to the mucosa (Ta), those that are high grade, flat, and confined to the epithelium (carcinoma in situ, CIS), and those that invade into the submucosa or lamina propria (T1). For patients with nonmuscle-invasive bladder cancer, the initial treatment is generally a complete cystoscopic transurethral resection of all visible bladder tumors (TURBT). Although most nonmuscle-invasive bladder cancers are safely and effectively treated by transurethral resection (TURBT) and/or intravesical instillation therapies, some forms have a high propensity to invade and progress and a more aggressive therapy is often required. Delaying cystectomy in these patients may lead to decreased disease-specific survival. Therefore, one of the biggest challenges in the management of nonmuscle-invasive bladder cancer is the decision regarding when to abandon conservative therapy and to proceed with radical cystectomy. This chapter discusses the role of radical cystectomy as the initial treatment of nonmuscle-invasive bladder cancer.

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Author information

Authors and Affiliations

  1. Department of Urology and Urologic Oncology, Medical School of Hanover [MHH], Carl Neuberg Str. 1, 30625, Hannover, Germany

    Axel S. Merseburger (Consultant Urologist, Director Urologic Oncology)

Authors
  1. Sandra Waalkes
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  2. Axel S. Merseburger
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  3. Markus A. Kuczyk
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Corresponding author

Correspondence to Axel S. Merseburger .

Editor information

Editors and Affiliations

  1. Miller School of Medicine, Dept. Urology & Cell Biology & Anatomy, University of Miami, NW. 10th Avenue 1400, Miami, 33136, Florida, USA

    Vinata B. Lokeshwar

  2. , Department of Urology and Urologic Oncol, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover, 30625, Germany

    Axel S. Merseburger

  3. Klinik für Urologie und Kinderurologie, Universitätsklinikum Schleswig-Holstein, Arnold-Heller-Str. 7, Kiel, 24105, Germany

    Stefan H. Hautmann

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Waalkes, S., Merseburger, A.S., Kuczyk, M.A. (2011). Cystectomy for Nonmuscle-Invasive Bladder Cancer. In: Lokeshwar, V., Merseburger, A., Hautmann, S. (eds) Bladder Tumors:. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-60761-928-4_15

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  • DOI: https://doi.org/10.1007/978-1-60761-928-4_15

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-927-7

  • Online ISBN: 978-1-60761-928-4

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