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Infection and the Kidney

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Studies on Renal Disorders

Abstract

Reactive oxygen species (ROS) are formed as a result of physiologic cellular metabolism, and a homeostatic balance exists between the formation of ROS and their removal by antioxidant scavenging compounds. Host–pathogen interaction results in a variety of responses, which include phagocytosis of the pathogen, release of cytokines, secretion of toxins, as well as production of ROS, leading to oxidative stress in the kidney. Oxidative stress is widely recognized as an important feature of urinary tract infection, pyelonephritis, and in sepsis kidney. Innate immunity toll-like receptors (TLR) are involved in the pathogen recognition and ROS may mediate its initiation and function. Efforts must be made to identify the precise contribution of these factors in infection process in order to clarify the mechanisms associated with kidney disease. This will certainly lead to discovery of therapeutic strategies in the future.

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Authors and Affiliations

  1. Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, 199, Tun-Hua North Road, Taipei, Taiwan

    Chih-Wei Yang

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  1. Chih-Wei Yang
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Correspondence to Chih-Wei Yang .

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Editors and Affiliations

  1. Graduate School of Medicine, Division of Molecular Medicine and Thera, Tohoku University, Seiryo-machi 2-1, Sendai, 980-8575, Japan

    Toshio Miyata

  2. Medizinische Klinik IV, Universitätsklinikum Erlangen, Krankenhausstr. 12, Erlangen, 91054, Germany

    Kai-Uwe Eckardt

  3. Graduate School of Medicine &, Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Tokyo, 113-8655, Japan

    Masaomi Nangaku

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Yang, CW. (2011). Infection and the Kidney. In: Miyata, T., Eckardt, KU., Nangaku, M. (eds) Studies on Renal Disorders. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press. https://doi.org/10.1007/978-1-60761-857-7_14

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