Neuroleptic Malignant Syndrome

  • Stanley N. CaroffEmail author
  • Stephan C. Mann
  • Kenneth A. Sullivan
  • E. Cabrina Campbell
Part of the Current Clinical Neurology book series (CCNEU)


Since the original description of neuroleptic malignant syndrome (NMS) over 50 years ago, a wealth of clinical data has accumulated on the clinical features, treatment, and pathogenesis of this uncommon but potentially lethal drug reaction. As a result, substantial progress has been achieved in reducing the incidence and mortality of NMS by increasing acceptance, awareness, and recognition of the disorder, more conservative prescribing practices, reduction of proposed risk factors, and development and marketing of newer antipsychotics with less liability for extrapyramidal side effects. Early diagnosis, cessation of neuroleptic medications, prompt medical intervention, and consideration of specific remedies comprise the mainstay of management. Nevertheless, vigilance must be maintained, as NMS remains obscure to most clinicians in practice. It is therefore essential for all physicians to become familiar with the diagnosis and treatment of this serious and treatable drug reaction.


Dopamine Agonist Neuroleptic Malignant Syndrome Malignant Hyperthermia Malignant Hyperthermia Neuroleptic Medication 
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Stanley N. Caroff
    • 1
    Email author
  • Stephan C. Mann
    • 2
    • 3
  • Kenneth A. Sullivan
    • 4
  • E. Cabrina Campbell
    • 4
  1. 1.Department of PsychiatryVeterans Affairs Medical Center and the University of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of Psychiatry and Behavioral ScienceThe University of Louisville School of MedicineLouisvilleUSA
  3. 3.Central Montgomery Mental Health and Mental Retardation CenterNorristownUSA
  4. 4.Department of PsychiatryVeterans Affairs Medical Center, University of Pennsylvania School of MedicinePhiladelphiaUSA

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