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The Role of Progenitor Cells in Lung Disease Prognosis

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Book cover Stem Cells in the Respiratory System

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

The number of investigations related to the role of stem and progenitor cells in lung repair has grown exponentially in recent years. Bone-marrow-derived cells, including stem cells and progenitors, have emerged as candidate markers to prognosticate outcomes during pulmonary disease. The relationship of these cells to prognosis has provided clues regarding the pathophysiologic characteristics of pulmonary disease, and direction for investigations related to lung repair. The ability of a progenitor population to participate in structural and paracrine processes in the lung paves the way for additional investigations of these cells as biomarkers in a variety of lung diseases, as well as to validate previous observations related to prognosis in these lung diseases. Many questions remain regarding the hierarchy and abilities of circulating hematopoietic stem cells, mesenchymal stem cells, and endogenous progenitor cells; however, correlations between the numbers and functions of these cells and pulmonary disease prognosis have been reported. Here we provide a detailed analysis of the relationship between these progenitors and the course of specific pulmonary diseases, including asthma, pulmonary arterial hypertension, pulmonary fibrosis, chronic obstructive pulmonary disease, acute lung injury, and lung cancer.

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Acknowledgments

The authors wish to thank Serpil Erzerum and Kewal Asosingh, who aided in the provision of figures for this manuscript.

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Authors and Affiliations

  1. Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver School of Medicine, Aurora, CO, 80045, USA

    Ellen L. Burnham, Susan Majka & Marc Moss

  2. Division of Cardiology, Charles C. Gates Regenerative Medicine and Stem Cell Biology Program, University of Colorado Denver, Aurora, CO, 80045, USA

    Susan Majka

Authors
  1. Ellen L. Burnham
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  2. Susan Majka
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Corresponding author

Correspondence to Ellen L. Burnham .

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Editors and Affiliations

  1. Dept. Medicine, Div. Pulmonary, Allergy & Critical, Emory University, Michael St. 615, Atlanta, 30322, USA

    Mauricio Rojas

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Burnham, E.L., Majka, S., Moss, M. (2010). The Role of Progenitor Cells in Lung Disease Prognosis. In: Rojas, M. (eds) Stem Cells in the Respiratory System. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-775-4_3

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