BK, JC, and Parvovirus Infections in Patients with Hematologic Malignancies

  • Véronique Erard
  • Michael Boeckh
Part of the Current Clinical Oncology book series (CCO)


The polyomaviruses, BK and JC virus, as well as parvoviruses are emerging infections in patients with hematologic malignancies and hematopoietic cell transplant recipients. BK virus has a predilection to the urinary tract and may cause hemorrhagic cystitis and nephritis. BK viremia appears to be an important marker and predictor for BK disease in immunocompromised patients. No well-established treatment options exist, but cidofovir has been used in addition to supportive care measures. JC virus is the cause of progressive multifocal leukoencephalopathy in immunosuppressed patients. The optimal treatment is not defined. There is increasing evidence that parvoviruses may also cause serious disease in immunocompromised patients, including anemia, pericarditis, myocarditis, hepatitis, pneumonitis, and neurologic disease. The frequency of these complications of parvoviruses is presently poorly defined. Treatment consists of intravenous immunoglobulin; no specific antiviral treatment exists. This chapter will review the epidemiology, disease manifestations, and diagnostic and management options for polyomaviruses and parvoviruses in patients with hematologic malignancies.


Polyomavirus BKV JC virus Viremia Prog-ressive multifocal leukoencephalopathy Immunosuppressed patients Cancer Stem cell transplantation Hemorrhagic cystitis Nephritis 



Michael Boeckh was supported in part by National Institute of Health grants CA18029 and HL93294.


  1. 1.
    Gardner SD, Field AM, Coleman DV, Hulme B. New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet. 1971;1(7712):1253–7.PubMedCrossRefGoogle Scholar
  2. 2.
    Hirsch HH, Steiger J, Polyomavirus BK. Lancet Infect Dis. 2003;3:611–23.PubMedCrossRefGoogle Scholar
  3. 3.
    Randhawa PS, Demetris AJ. Nephropathy due to polyomavirus type BK. N Engl J Med. 2000;342(18):1361–3.PubMedCrossRefGoogle Scholar
  4. 4.
    Apperley JF, Rice SJ, Bishop JA, et al. Late-onset hemorrhagic cystitis associated with urinary excretion of polyomaviruses after bone marrow transplantation. Transplantation. 1987;43(1):108–12.PubMedCrossRefGoogle Scholar
  5. 5.
    Arthur RR, Shah KV, Charache P, Saral R. BK and JC virus infections in recipients of bone marrow transplants. J Infect Dis. 1988;158(3):563–9.PubMedCrossRefGoogle Scholar
  6. 6.
    Cubitt CL. Molecular genetics of the BK virus. Adv Exp Med Biol. 2006;577:85–95.PubMedCrossRefGoogle Scholar
  7. 7.
    Drachenberg CB, Papadimitriou JC, Wali R, Cubitt CL, Ramos E. BK polyoma virus allograft nephropathy: ultrastructural features from viral cell entry to lysis. Am J Transplant. 2003;3(11):1383–92.PubMedCrossRefGoogle Scholar
  8. 8.
    Jiang M, Abend JR, Tsai B, Imperiale MJ. Early events during BK virus entry and disassembly. J Virol. 2009;83(3):1350–8.PubMedCrossRefGoogle Scholar
  9. 9.
    Moriyama T, Sorokin A. BK virus (BKV): infection, propagation, quantitation, purification, labeling, and analysis of cell entry. Curr Protoc Cell Biol. 2009;Chapter 26:Unit 26.2.Google Scholar
  10. 10.
    Marsh M, Helenius A. Virus entry: open sesame. Cell. 2006;124(4):729–40.PubMedCrossRefGoogle Scholar
  11. 11.
    Eash S, Querbes W, Atwood WJ. Infection of vero cells by BK virus is dependent on caveolae. J Virol. 2004;78(21):11583–90.PubMedCrossRefGoogle Scholar
  12. 12.
    Ashok A, Atwood WJ. Virus receptors and tropism. Adv Exp Med Biol. 2006;577:60–72.PubMedCrossRefGoogle Scholar
  13. 13.
    Low JA, Magnuson B, Tsai B, Imperiale MJ. Identification of gangliosides GD1b and GT1b as receptors for BK virus. J Virol. 2006;80(3):1361–6.PubMedCrossRefGoogle Scholar
  14. 14.
    Moriyama T, Marquez JP, Wakatsuki T, Sorokin A. Caveolar endocytosis is critical for BK virus infection of human renal proximal tubular epithelial cells. J Virol. 2007;81(16):8552–62.PubMedCrossRefGoogle Scholar
  15. 15.
    Knowles WA. Discovery and epidemiology of the human polyomaviruses BK virus (BKV) and JC virus (JCV). Adv Exp Med Biol. 2006;577:19–45.PubMedCrossRefGoogle Scholar
  16. 16.
    Pietropaolo V, Di Taranto C, Degener AM, et al. Transplacental transmission of human polyomavirus BK. J Med Virol. 1998;56(4):372–6.PubMedCrossRefGoogle Scholar
  17. 17.
    Shah K, Daniel R, Madden D, Stagno S. Serological investigation of BK papovavirus infection in pregnant women and their offspring. Infect Immun. 1980;30(1):29–35.PubMedGoogle Scholar
  18. 18.
    Coleman DV, Wolfendale MR, Daniel RA, et al. A prospective study of human polyomavirus infection in pregnancy. J Infect Dis. 1980;142(1):1–8.PubMedCrossRefGoogle Scholar
  19. 19.
    Vanchiere JA, Nicome RK, Greer JM, Demmler GJ, Butel JS. Frequent detection of polyomaviruses in stool samples from hospitalized children. J Infect Dis. 2005;192(4):658–64.PubMedCrossRefGoogle Scholar
  20. 20.
    Bofill-Mas S, Formiga-Cruz M, Clemente-Casares P, Calafell F, Girones R. Potential transmission of human polyomaviruses through the gastrointestinal tract after exposure to virions or viral DNA. J Virol. 2001;75(21):10290–9.PubMedCrossRefGoogle Scholar
  21. 21.
    Bohl DL, Storch GA, Ryschkewitsch C, et al. Donor origin of BK virus in renal transplantation and role of HLA C7 in susceptibility to sustained BK viremia. Am J Transplant. 2005;5(9):2213–21.PubMedCrossRefGoogle Scholar
  22. 22.
    Hirsch HH. Polyomavirus BK nephropathy: a (re-)emerging complication in renal transplantation. Am J Transplant. 2002;2:25–30.PubMedCrossRefGoogle Scholar
  23. 23.
    Goudsmit J, Wertheim-van Dillen P, van Strien A, van der Noordaa J. The role of BK virus in acute respiratory tract disease and the presence of BKV DNA in tonsils. J Med Virol. 1982;10(2):91–9.PubMedCrossRefGoogle Scholar
  24. 24.
    Feder Jr HM, Solomon B, Gavin LD. Polyoma virus hemorrhagic cystitis in an otherwise normal child. Pediatr Infect Dis J. 2008;27(10):948–9.PubMedCrossRefGoogle Scholar
  25. 25.
    Nickeleit V, Singh HK, Mihatsch MJ. Polyomavirus nephropathy: morphology, pathophysiology, and clinical management. Curr Opin Nephrol Hypertens. 2003;12(6):599–605.PubMedCrossRefGoogle Scholar
  26. 26.
    Monini P, Rotola A, Di Luca D, et al. DNA rearrangements impairing BK virus productive infection in urinary tract tumors. Virology. 1995;214(1):273–9.PubMedCrossRefGoogle Scholar
  27. 27.
    Doerries K. Human polyomavirus JC and BK persistent infection. Adv Exp Med Biol. 2006;577:102–16.PubMedCrossRefGoogle Scholar
  28. 28.
    Arthur RR, Dagostin S, Shah KV. Detection of BK virus and JC virus in urine and brain tissue by the polymerase chain reaction. J Clin Microbiol. 1989;27(6):1174–9.PubMedGoogle Scholar
  29. 29.
    Chang D, Wang M, Ou WC, Lee MS, Ho HN, Tsai RT. Genotypes of human polyomaviruses in urine samples of pregnant women in Taiwan. J Med Virol. 1996;48(1):95–101.PubMedCrossRefGoogle Scholar
  30. 30.
    Egli A, Infanti L, Dumoulin A, et al. Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors. J Infect Dis. 2009;199(6):837–46.PubMedCrossRefGoogle Scholar
  31. 31.
    Hirsch HH, Brennan DC, Drachenberg CB, et al. Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations. Transplantation. 2005;79(10):1277–86.PubMedCrossRefGoogle Scholar
  32. 32.
    Hirsch HH, Drachenberg CB, Steiger J, Ramos E. Polyomavirus-associated nephropathy in renal transplantation: critical issues of screening and management. Adv Exp Med Biol. 2006;577:160–73.PubMedCrossRefGoogle Scholar
  33. 33.
    Nickeleit V, Mihatsch MJ. Polyomavirus allograft nephropathy and concurrent acute rejection: a diagnostic and therapeutic challenge. Am J Transplant. 2004;4(5):838–9.PubMedCrossRefGoogle Scholar
  34. 34.
    O’Donnell PH, Swanson K, Josephson MA. BK virus infection is associated with hematuria and renal impairment in recipients of allogeneic hematopoetic stem cell transplants. Biol Blood Marrow Transplant. 2009;15(9):1038–48. e1.PubMedCrossRefGoogle Scholar
  35. 35.
    Inaba H, Jones DP, Gaber LW, et al. BK virus-induced tubulointerstitial nephritis in a child with acute lymphoblastic leukemia.J Pediatr. 2007;151(2):215–7.PubMedCrossRefGoogle Scholar
  36. 36.
    van der Bij A, Betjes M, Weening J, et al. BK virus nephropathy in an immunodeficient patient with chronic lymphocytic leukemia. J Clin Virol. 2009;45(4):341–4.PubMedCrossRefGoogle Scholar
  37. 37.
    Lekakis LJ, Macrinici V, Baraboutis IG, Mitchell B, Howard DS. BK virus nephropathy after allogeneic stem cell transplantation: a case report and literature review. Am J Hematol. 2009;84(4):243–6.PubMedCrossRefGoogle Scholar
  38. 38.
    Limaye AP, Smith KD, Cook L, et al. Polyomavirus nephropathy in native kidneys of non-renal transplant recipients. Am J Transplant. 2005;5(3):614–20.PubMedGoogle Scholar
  39. 39.
    Shapiro S, Robin M, Esperou H, et al. Polyomavirus nephropathy in the native kidneys of an unrelated cord blood transplant recipient followed by a disseminated polyomavirus infection. Transplantation. 2006;82(2):292–3.PubMedCrossRefGoogle Scholar
  40. 40.
    Bruno B, Zager R, Boeckh M, Gooley T, Myerson DH, Huang M, et al. Adenovirus nephritis in hematopoietic stem cell transplantation. Transplantation. 2004;77:1049–57.PubMedCrossRefGoogle Scholar
  41. 41.
    Bedi A, Miller CB, Hanson JL, et al. Association of BK virus with failure of prophylaxis against hemorrhagic cystitis following bone marrow transplantation. J Clin Oncol. 1995;13(5):1103–9.PubMedGoogle Scholar
  42. 42.
    Iwamoto S, Azuma E, Hori H, et al. BK virus-associated fatal renal failure following late-onset hemorrhagic cystitis in an unrelated bone marrow transplantation. Pediatr Hematol Oncol. 2002;19(4):255–61.PubMedCrossRefGoogle Scholar
  43. 43.
    Seber A, Shu XO, Defor T, Sencer S, Ramsay N. Risk factors for severe hemorrhagic cystitis following BMT. Bone Marrow Transplant. 1999;23(1):35–40.PubMedCrossRefGoogle Scholar
  44. 44.
    Leung AY, Mak R, Lie AK, et al. Clinicopathological features and risk factors of clinically overt haemorrhagic cystitis complicating bone marrow transplantation. Bone Marrow Transplant. 2002;29(6):509–13.PubMedCrossRefGoogle Scholar
  45. 45.
    Hu RQ, Mehter H, Nadasdy T, et al. Severe hemorrhagic cystitis associated with prolonged oral cyclophosphamide therapy: case report and literature review. Rheumatol Int. 2008;28(11):1161–4.PubMedCrossRefGoogle Scholar
  46. 46.
    Erard V, Kim HW, Corey L, et al. BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients. Blood. 2005;106(3):1130–2.PubMedCrossRefGoogle Scholar
  47. 47.
    Schuchter LM, Hensley ML, Meropol NJ, Winer EP. 2002 update of recommendations for the use of chemotherapy and radiotherapy protectants: clinical practice guidelines of the American Society of Clinical Oncology. J Clin Oncol. 2002;20(12):2895–903.PubMedCrossRefGoogle Scholar
  48. 48.
    Hadjibabaie M, Alimoghaddam K, Shamshiri AR, et al. Continuous bladder irrigation prevents hemorrhagic cystitis after allogeneic hematopoietic cell transplantation. Urol Oncol. 2008;26(1):43–6.PubMedCrossRefGoogle Scholar
  49. 49.
    Shepherd JD, Pringle LE, Barnett MJ, Klingemann HG, Reece DE, Phillips GL. Mesna versus hyperhydration for the prevention of cyclophosphamide-induced hemorrhagic cystitis in bone marrow transplantation. J Clin Oncol. 1991;9(11):2016–20.PubMedGoogle Scholar
  50. 50.
    Garcia Ligero J, Mora Peris B, Garcia Garcia F. Hemorrhagic cystitis caused by BK and JC polyomavirus in patients treated with bone marrow transplantation: clinical features and urologic management. Actas Urol Esp. 2002;26(2):104–10.PubMedCrossRefGoogle Scholar
  51. 51.
    Erard V, Storer B, Corey L, et al. BK virus infection in hematopoietic stem cell transplant recipients: frequency, risk factors, and association with postengraftment hemorrhagic cystitis. Clin Infect Dis. 2004;39(12):1861–5.PubMedCrossRefGoogle Scholar
  52. 52.
    Gorczynska E, Turkiewicz D, Rybka K, et al. Incidence, clinical outcome, and management of virus-induced hemorrhagic cystitis in children and adolescents after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2005;11(10):797–804.PubMedCrossRefGoogle Scholar
  53. 53.
    Fioriti D, Degener AM, Mischitelli M, et al. BKV infection and hemorrhagic cystitis after allogeneic bone marrow transplant. Int J Immunopathol Pharmacol. 2005;18(2):309–16.PubMedGoogle Scholar
  54. 54.
    Giraud G, Priftakis P, Bogdanovic G, et al. BK-viruria and haemorrhagic cystitis are more frequent in allogeneic haematopoietic stem cell transplant patients receiving full conditioning and unrelated-HLA-mismatched grafts. Bone Marrow Transplant 2008.Google Scholar
  55. 55.
    Cesaro S, Facchin C, Tridello G, et al. A prospective study of BK-virus-associated haemorrhagic cystitis in paediatric patients undergoing allogeneic haematopoietic stem cell transplantation. Bone Marrow Transplant. 2008;41(4):363–70.PubMedCrossRefGoogle Scholar
  56. 56.
    Park SH, Choi SM, Lee DG, et al. Infectious complications associated with alemtuzumab use for allogeneic hematopoietic stem cell transplantation: comparison with anti-thymocyte globulin. Transpl Infect Dis. 2009;11:413–23.PubMedCrossRefGoogle Scholar
  57. 57.
    Gaziev J, Paba P, Miano R, et al. Late-onset hemorrhagic cystitis in children after hematopoietic stem cell transplantation for thalassemia and sickle cell anemia: a prospective evaluation of polyoma (BK) virus infection and treatment with cidofovir. Biol Blood Marrow Transplant. 2010;16(5):662–71.PubMedCrossRefGoogle Scholar
  58. 58.
    De Padua Silva L, Patah PA, Saliba RM, et al. Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplants is the complex result of BK virus infection, preparative regimen intensity and donor type. Haematologica 2010.Google Scholar
  59. 59.
    Stracke S, Helmchen U, von Muller L, Bunjes D, Keller F. Polyoma virus-associated interstitial nephritis in a patient with acute myeloic leukaemia and peripheral blood stem cell transplantation. Nephrol Dial Transplant. 2003;18(11):2431–3.PubMedCrossRefGoogle Scholar
  60. 60.
    Verghese PS, Finn LS, Englund JA, Sanders JE, Hingorani SR. BK nephropathy in pediatric hematopoietic stem cell transplant recipients. Pediatr Transplant. 2009;13(7):913–8.PubMedCrossRefGoogle Scholar
  61. 61.
    Galan A, Rauch CA, Otis CN. Fatal BK polyoma viral pneumonia associated with immunosuppression. Hum Pathol. 2005;36(9):1031–4.PubMedCrossRefGoogle Scholar
  62. 62.
    Sandler ES, Aquino VM, Goss-Shohet E, Hinrichs S, Krisher K. BK papova virus pneumonia following hematopoietic stem cell transplantation. Bone Marrow Transplant. 1997;20(2):163–5.PubMedCrossRefGoogle Scholar
  63. 63.
    Asano Y, Kanda Y, Ogawa N, et al. Male predominance among Japanese adult patients with late-onset hemorrhagic cystitis after hematopoietic stem cell transplantation. Bone Marrow Transplant. 2003;32(12):1175–9.PubMedCrossRefGoogle Scholar
  64. 64.
    Bielorai B, Shulman LM, Rechavi G, Toren A. CMV reactivation induced BK virus-associated late onset hemorrhagic cystitis after peripheral blood stem cell transplantation. Bone Marrow Transplant. 2001;28(6):613–4.PubMedCrossRefGoogle Scholar
  65. 65.
    Basquiera AL, Calafat P, Parodi JM, De Diller AB, Zlocowski JC, Caeiro JP. Cytomegalovirus-induced haemorrhagic cystitis in a patient with neurogenic bladder. Scand J Infect Dis. 2003;35(11–12):902–4.PubMedGoogle Scholar
  66. 66.
    Priftakis P, Bogdanovic G, Kokhaei P, Mellstedt H, Dalianis T. BK virus quantification in urine samples of bone marrow transplanted patients is helpful for diagnosis of hemorrhagic cystitis, although wide individual variations exist. J Clin Virol. 2002.Google Scholar
  67. 67.
    Arthur RR, Shah KV, Baust SJ, Santos GW, Saral R. Association of BK viruria with hemorrhagic cystitis in recipients of bone marrow transplants. N Engl J Med. 1986;315(4):230–4.PubMedCrossRefGoogle Scholar
  68. 68.
    Bogdanovic G, Priftakis P, Giraud G, et al. Association between a high BK virus load in urine samples of patients with graft-versus-host disease and development of hemorrhagic cystitis after hematopoietic stem cell transplantation. J Clin Microbiol. 2004;42(11):5394–6.PubMedCrossRefGoogle Scholar
  69. 69.
    Leung AY, Chan M, Tang SC, Liang R, Kwong YL. Real-time quantitative analysis of polyoma BK viremia and viruria in renal allograft recipients. J Virol Methods. 2002;103(1):51–6.PubMedCrossRefGoogle Scholar
  70. 70.
    Wong AS, Chan KH, Cheng VC, Yuen KY, Kwong YL, Leung AY. Relationship of pretransplantation polyoma BK virus serologic findings and BK viral reactivation after hematopoietic stem cell transplantation. Clin Infect Dis. 2007;44(6):830–7.PubMedCrossRefGoogle Scholar
  71. 71.
    Hirsch HH, Knowles W, Dickenmann M, et al. Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. N Engl J Med. 2002;347(7):488–96.PubMedCrossRefGoogle Scholar
  72. 72.
    Leung AY, Suen CK, Lie AK, Liang RH, Yuen KY, Kwong YL. Quantification of polyoma BK viruria in hemorrhagic cystitis complicating bone marrow transplantation. Blood. 2001;98(6):1971–8.PubMedCrossRefGoogle Scholar
  73. 73.
    Xie Y, Han Y, Wu DP. The role of BK polyomavirus in the development of hemorrhagic cystitis after hematopoietic stem cell transplantation. Zhonghua Nei Ke Za Zhi. 2008;47(9):746–9.PubMedGoogle Scholar
  74. 74.
    Parkin RK, Boeckh MJ, Erard V, Huang ML, Myerson D. Specific delineation of BK polyomavirus in kidney tissue with a digoxigenin-labeled DNA probe. Mol Cell Probes. 2005;19(2):87–92.PubMedCrossRefGoogle Scholar
  75. 75.
    Fogazzi GB, Cantu M, Saglimbeni L. ‘Decoy cells’ in the urine due to polyomavirus BK infection: easily seen by phase-contrast microscopy. Nephrol Dial Transplant. 2001;16(7):1496–8.PubMedCrossRefGoogle Scholar
  76. 76.
    Boldorini R, Veggiani C, Barco D, Monga G. Kidney and urinary tract polyomavirus infection and distribution: molecular biology investigation of 10 consecutive autopsies. Arch Pathol Lab Med. 2005;129(1):69–73.PubMedGoogle Scholar
  77. 77.
    Hiraoka A, Ishikawa J, Kitayama H, et al. Hemorrhagic cystitis after bone marrow transplantation: importance of a thin sectioning technique on urinary sediments for diagnosis. Bone Marrow Transplant. 1991;7(2):107–11.PubMedGoogle Scholar
  78. 78.
    Randhawa P, Vats A, Shapiro R. Monitoring for polyomavirus BK and JC in urine: comparison of quantitative polymerase chain reaction with urine cytology. Transplantation. 2005;79(8):984–6.PubMedCrossRefGoogle Scholar
  79. 79.
    Semple K, Lovchik J, Drachenberg C. Identification of polyoma BK virus in kidney transplant recipients by shell vial cell culture assay and urine cytology. Am J Clin Pathol. 2006;126(3):444–7.PubMedCrossRefGoogle Scholar
  80. 80.
    Hoffman NG, Cook L, Atienza EE, Limaye AP, Jerome KR. Marked variability of BK virus load measurement using quantitative real-time PCR among commonly used assays. J Clin Microbiol. 2008;46(8):2671–80.PubMedCrossRefGoogle Scholar
  81. 81.
    Dropulic LK, Jones RJ. Polyomavirus BK infection in blood and marrow transplant recipients. Bone Marrow Transplant. 2008;41(1):11–8.PubMedCrossRefGoogle Scholar
  82. 82.
    Ambinder RF, Burns W, Forman M, et al. Hemorrhagic cystitis associated with adenovirus infection in bone marrow transplantation. Arch Intern Med. 1986;146(7):1400–1.PubMedCrossRefGoogle Scholar
  83. 83.
    Spach DH, Bauwens JE, Myerson D, Mustafa MM, Bowden RA. Cytomegalovirus-induced hemorrhagic cystitis following bone marrow transplantation. Clin Infect Dis. 1993;16(1):142–4.PubMedCrossRefGoogle Scholar
  84. 84.
    Fergany AF, Moussa AS, Gill IS. Laparoscopic cystoprostatectomy for radiation-induced hemorrhagic cystitis. J Endourol. 2009;23(2): 275–8.PubMedCrossRefGoogle Scholar
  85. 85.
    Cesaro S, Hirsch HH, Faraci M, et al. Cidofovir for BK virus-associated hemorrhagic cystitis: a retrospective study. Clin Infect Dis. 2009;49(2):233–40.PubMedCrossRefGoogle Scholar
  86. 86.
    Williams JW, Javaid B, Kadambi PV, et al. Leflunomide for polyomavirus type BK nephropathy. N Engl J Med. 2005;352(11): 1157–8.PubMedCrossRefGoogle Scholar
  87. 87.
    Farasati NA, Shapiro R, Vats A, Randhawa P. Effect of leflunomide and cidofovir on replication of BK virus in an in vitro culture system. Transplantation. 2005;79(1):116–8.PubMedCrossRefGoogle Scholar
  88. 88.
    Josephson MA, Gillen D, Javaid B, et al. Treatment of renal allograft polyoma BK virus infection with leflunomide. Transplantation. 2006;81(5):704–10.PubMedCrossRefGoogle Scholar
  89. 89.
    Josephson MA, Williams JW, Chandraker A, Randhawa PS. Polyomavirus-associated nephropathy: update on antiviral strategies. Transpl Infect Dis. 2006;8(2):95–101.PubMedCrossRefGoogle Scholar
  90. 90.
    Lamoth F, Pascual M, Erard V, Venetz JP, Nseir G, Meylan P. Low-dose cidofovir for the treatment of polyomavirus-associated nephropathy: two case reports and review of the literature. Antivir Ther. 2008;13(8):1001–9.PubMedGoogle Scholar
  91. 91.
    Savona MR, Newton D, Frame D, Levine JE, Mineishi S, Kaul DR. Low-dose cidofovir treatment of BK virus-associated hemorrhagic cystitis in recipients of hematopoietic stem cell transplant. Bone Marrow Transplant. 2007;39(12):783–7.PubMedCrossRefGoogle Scholar
  92. 92.
    Leung AY, Chan MT, Yuen KY, et al. Ciprofloxacin decreased polyoma BK virus load in patients who underwent allogeneic hematopoietic stem cell transplantation. Clin Infect Dis. 2005;40(4):528–37.PubMedCrossRefGoogle Scholar
  93. 93.
    Rao KV, Buie LW, Shea T, et al. Intravesicular cidofovir for the management of BK virus-associated cystitis. Biol Blood Marrow Transplant. 2009;15(3):391–2.PubMedCrossRefGoogle Scholar
  94. 94.
    Sener A, House AA, Jevnikar AM, et al. Intravenous immunoglobulin as a treatment for BK virus associated nephropathy: one-year follow-up of renal allograft recipients. Transplantation. 2006;81(1):117–20.PubMedCrossRefGoogle Scholar
  95. 95.
    Wadei HM, Rule AD, Lewin M, et al. Kidney transplant function and histological clearance of virus following diagnosis of polyomavirus-associated nephropathy (PVAN). Am J Transplant. 2006;6(5 Pt 1):1025–32.PubMedCrossRefGoogle Scholar
  96. 96.
    Bernhoff E, Gutteberg TJ, Sandvik K, Hirsch HH, Rinaldo CH. Cidofovir inhibits polyomavirus BK replication in human renal tubular cells downstream of viral early gene expression. Am J Transplant. 2008;8(7):1413–22.PubMedCrossRefGoogle Scholar
  97. 97.
    Rho YH, Oeser A, Chung CP, Milne GL, Stein CM. Drugs used in the treatment of rheumatoid arthritis: relationship between current use and cardiovascular risk factors. Arch Drug Inf. 2009;2(2):34–40.PubMedCrossRefGoogle Scholar
  98. 98.
    Canivet C, Rostaing L, Galvani S, et al. Polyoma BK virus-associated nephropathy in kidney-transplant patients: effects of leflunomide on T-cell functions and disease outcome. Int Immunopharmacol. 2009;9(9):1131–6.PubMedCrossRefGoogle Scholar
  99. 99.
    Faguer S, Hirsch HH, Kamar N, et al. Leflunomide treatment for polyomavirus BK-associated nephropathy after kidney transplantation. Transpl Int. 2007;20(11):962–9.PubMedCrossRefGoogle Scholar
  100. 100.
    Ali SH, Chandraker A, DeCaprio JA. Inhibition of simian virus 40 large T antigen helicase activity by fluoroquinolones. Antivir Ther. 2007;12(1):1–6.PubMedGoogle Scholar
  101. 101.
    Puliyanda D AN, Dhavan A, et al. Heart and bone marrow transplant recipients are at low risk for BK viremia and nephropathy. Am J Transplant. 2003;3:510.Google Scholar
  102. 102.
    Hilton R, Tong CY. Antiviral therapy for polyomavirus-associated nephropathy after renal transplantation. J Antimicrob Chemother. 2008;62(5):855–9.PubMedCrossRefGoogle Scholar
  103. 103.
    Held TK, Biel SS, Nitsche A, et al. Treatment of BK virus-associated hemorrhagic cystitis and simultaneous CMV reactivation with cidofovir. Bone Marrow Transplant. 2000;26(3):347–50.PubMedCrossRefGoogle Scholar
  104. 104.
    Bridges B, Donegan S, Badros A. Cidofovir bladder instillation for the treatment of BK hemorrhagic cystitis after allogeneic stem cell transplantation. Am J Hematol. 2006;81(7):535–7.PubMedCrossRefGoogle Scholar
  105. 105.
    Walden O, Hartel C, Doehn C, Jocham D. Intravesical cidofovir – instillation therapy for polyomavirus-associated hemorrhagic cystitis after bone marrow transplantation. Urologe A. 2007;46(5):535–7.PubMedCrossRefGoogle Scholar
  106. 106.
    Avery RK, Bolwell BJ, Yen-Lieberman B, et al. Use of leflunomide in an allogeneic bone marrow transplant recipient with refractory cytomegalovirus infection. Bone Marrow Transplant. 2004;34(12):1071–5.PubMedCrossRefGoogle Scholar
  107. 107.
    Ehlert K, Groll AH, Kuehn J, Vormoor J. Treatment of refractory CMV-infection following hematopoietic stem cell transplantation with the combination of foscarnet and leflunomide. Klin Pädiatr. 2006;218(3):180–4.PubMedCrossRefGoogle Scholar
  108. 108.
    Leung AYHY, K.Y, Kwong YL. Anti-BK virus activity of ciprofloxacin and related antibiotics. 2005.Google Scholar
  109. 109.
    Randhawa PS. Anti-BK virus activity of ciprofloxacin and related antibiotics. Clin Infect Dis. 2005;41(9):1366–7.PubMedCrossRefGoogle Scholar
  110. 110.
    Stoner GL, Alappan R, Jobes DV, Ryschkewitsch CF, Landry ML. BK virus regulatory region rearrangements in brain and cerebrospinal fluid from a leukemia patient with tubulointerstitial nephritis and meningoencephalitis. Am J Kidney Dis. 2002;39(5): 1102–12.PubMedCrossRefGoogle Scholar
  111. 111.
    Lesprit P, Chaline-Lehmann D, Authier FJ, Ponnelle T, Gray F, Levy Y. BK virus encephalitis in a patient with AIDS and lymphoma. AIDS. 2001;15(9):1196–9.PubMedCrossRefGoogle Scholar
  112. 112.
    Coppo P, Laporte JP, Aoudjhane M, et al. Progressive multifocal leucoencephalopathy with peripheral demyelinating neuropathy after autologous bone marrow transplantation for acute myeloblastic leukemia (FAB5). Bone Marrow Transplant. 1999;23(4):401–3.PubMedCrossRefGoogle Scholar
  113. 113.
    Re D, Bamborschke S, Feiden W, et al. Progressive multifocal leukoencephalopathy after autologous bone marrow transplantation and alpha-interferon immunotherapy. Bone Marrow Transplant. 1999;23(3):295–8.PubMedCrossRefGoogle Scholar
  114. 114.
    Holzapfel C, Kellinghaus C, Luttmann R, et al. Progressive multifocal leukoencephalopathy (PML) in chronic lymphatic leukemia (CLL). Review of the literature and case report. Nervenarzt. 2002;73(6):543–7.PubMedCrossRefGoogle Scholar
  115. 115.
    Seong D, Bruner JM, Lee KH, et al. Progressive multifocal leukoencephalopathy after autologous bone marrow transplantation in a patient with chronic myelogenous leukemia. Clin Infect Dis. 1996;23(2):402–3.PubMedCrossRefGoogle Scholar
  116. 116.
    Kharfan-Dabaja MA, Ayala E, Greene J, Rojiani A, Murtagh FR, Anasetti C. Two cases of progressive multifocal leukoencephalopathy after allogeneic hematopoietic cell transplantation and a review of the literature. Bone Marrow Transplant. 2007;39(2):101–7.PubMedCrossRefGoogle Scholar
  117. 117.
    Taoufik Y, Gasnault J, Karaterki A, et al. Prognostic value of JC virus load in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy. J Infect Dis. 1998;178(6):1816–20.PubMedCrossRefGoogle Scholar
  118. 118.
    Houston S, Roberts N, Mashinter L. Failure of cidofovir therapy in progressive multifocal leukoencephalopathy unrelated to human immunodeficiency virus. Clin Infect Dis. 2001;32:150–2.PubMedCrossRefGoogle Scholar
  119. 119.
    Focosi D, Fazzi R, Montanaro D, Emdin M, Petrini M. Progressive multifocal leukoencephalopathy in a haploidentical stem cell transplant recipient: a clinical, neuroradiological and virological response after treatment with risperidone. Antivir Res. 2007;74(2):156–8.PubMedCrossRefGoogle Scholar
  120. 120.
    Przepiorka D, Jaeckle KA, Birdwell RR, et al. Successful treatment of progressive multifocal leukoencephalopathy with low-dose interleukin-2. Bone Marrow Transplant. 1997;20(11):983–7.PubMedCrossRefGoogle Scholar
  121. 121.
    Dal Pozzo F, Andrei G, Lebeau I. In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA. Antivir Res. 2007;75(1):52–7.PubMedCrossRefGoogle Scholar
  122. 122.
    Kleinman SH, Glynn SA, Lee TH, et al. A linked donor-recipient study to evaluate parvovirus B19 transmission by blood component transfusion. Blood. 2009;114(17):3677–83.PubMedCrossRefGoogle Scholar
  123. 123.
    Azzi A, Fanci R, Ciappi S, Zakrzewska K, Bosi A. Human parvovirus B19 infection in bone marrow transplantation patients. Am J Hematol. 1993;44(3):207–9.PubMedCrossRefGoogle Scholar
  124. 124.
    Schleuning M, Jager G, Holler E, et al. Human parvovirus B19-associated disease in bone marrow transplantation. Infection. 1999;27(2):114–7.PubMedCrossRefGoogle Scholar
  125. 125.
    Florea AV, Ionescu DN, Melhem MF. Parvovirus B19 infection in the immunocompromised host. Arch Pathol Lab Med. 2007;131(5):799–804.PubMedGoogle Scholar
  126. 126.
    Eid AJ, Brown RA, Patel R, Razonable RR. Parvovirus B19 infection after transplantation: a review of 98 cases. Clin Infect Dis. 2006;43(1):40–8.PubMedCrossRefGoogle Scholar
  127. 127.
    Eid AJ, Posfay-barbe KM, AST Infectious Diseases Community of Practice. Parvovirus B19 in solid organ transplant recipients. Am J Transplant. 2009;9 Suppl 4:S147–50.PubMedCrossRefGoogle Scholar
  128. 128.
    Douvoyiannis M, Litman N, Goldman DL. Neurologic manifestations associated with parvovirus B19 infection. Clin Infect Dis. 2009;48(12):1713–23.PubMedCrossRefGoogle Scholar
  129. 129.
    Kurtzman G, Frickhofen N, Kimball J, Jenkins DW, Nienhuis AW, Young NS. Pure red-cell aplasia of 10 years’ duration due to persistent parvovirus B19 infection and its cure with immunoglobulin therapy [see comments]. N Engl J Med. 1989;321(8):519–23.PubMedCrossRefGoogle Scholar
  130. 130.
    Frickhofen N, Arnold R, Hertenstein B, Wiesneth M, Young NS. Parvovirus B19 infection and bone marrow transplantation. Ann Hematol. 1992;64(Suppl):A121–4.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.InfectiologieHFR-FribourgFribourgSwitzerland
  2. 2.Vaccine and Infectious Disease DivisionUniversity of Washington, Fred Hutchinson Cancer Research CenterSeattleUSA

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