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BK, JC, and Parvovirus Infections in Patients with Hematologic Malignancies

  • Véronique Erard
  • Michael Boeckh
Chapter
Part of the Current Clinical Oncology book series (CCO)

Abstract

The polyomaviruses, BK and JC virus, as well as parvoviruses are emerging infections in patients with hematologic malignancies and hematopoietic cell transplant recipients. BK virus has a predilection to the urinary tract and may cause hemorrhagic cystitis and nephritis. BK viremia appears to be an important marker and predictor for BK disease in immunocompromised patients. No well-established treatment options exist, but cidofovir has been used in addition to supportive care measures. JC virus is the cause of progressive multifocal leukoencephalopathy in immunosuppressed patients. The optimal treatment is not defined. There is increasing evidence that parvoviruses may also cause serious disease in immunocompromised patients, including anemia, pericarditis, myocarditis, hepatitis, pneumonitis, and neurologic disease. The frequency of these complications of parvoviruses is presently poorly defined. Treatment consists of intravenous immunoglobulin; no specific antiviral treatment exists. This chapter will review the epidemiology, disease manifestations, and diagnostic and management options for polyomaviruses and parvoviruses in patients with hematologic malignancies.

Keywords

Polyomavirus BKV JC virus Viremia Prog-ressive multifocal leukoencephalopathy Immunosuppressed patients Cancer Stem cell transplantation Hemorrhagic cystitis Nephritis 

Notes

Acknowledgments

Michael Boeckh was supported in part by National Institute of Health grants CA18029 and HL93294.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.InfectiologieHFR-FribourgFribourgSwitzerland
  2. 2.Vaccine and Infectious Disease DivisionUniversity of Washington, Fred Hutchinson Cancer Research CenterSeattleUSA

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