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Secondary, AA, Amyloidosis

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Amyloidosis

Part of the book series: Contemporary Hematology ((CH))

Abstract

AA amyloidosis, otherwise known as secondary amyloidosis, is a complication of chronic inflammation. The amyloid fibrils are derived from the hepatic acute phase reactant, serum amyloid A protein. Clinically AA amyloidosis has a predominantly renal presentation with proteinuria and renal impairment. Untreated disease will progress to end-stage renal failure. Treatment depends on complete control of the underlying chronic inflammatory condition, and if this can be achieved long-term outcomes are favourable. Median survival in patients with AA amyloidosis now exceeds 12 years although renal failure eventually develops in more than 40%.

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Authors and Affiliations

  1. Division of Medicine, UK National Amyloidosis Centre, University College London Medical School, London, UK

    Helen J. Lachmann MD, FRCP

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  1. Helen J. Lachmann MD, FRCP
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  1. Mayo Clinic, First Street SW. 200, Rochester, 55905, Minnesota, USA

    Morie A. Gertz

  2. Mayo Clinic, First Street SW. 200, Rochester, 55905, Minnesota, USA

    S. Vincent Rajkumar

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Lachmann, H.J. (2010). Secondary, AA, Amyloidosis. In: Gertz, M., Rajkumar, S. (eds) Amyloidosis. Contemporary Hematology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-631-3_13

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