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Mechanisms of Redox Signaling in Cardiovascular Disease

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Studies on Cardiovascular Disorders

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Abstract

Arrays of chemical oxidants are produced in healthy cells, where they function as important signaling molecules that are crucial in homeostatic regulation and cellular adaptation. The molecular basis of “redox signaling” is a series of oxido-reductive chemical reactions in which oxidants or reductants post-translationally alter the structure of proteins. These modifications equate to signal sensing events, in which an alteration in protein redox status may couple to a change in its function. This coupling of sensing to function is a true transduction event, allowing conversion of the cellular redox state into altered enzymatic activities. Here we review redox signaling in the cardiovascular system, considering the variety of post-translational oxidative modifications that explain redox sensing and signal transduction by proteins at the molecular level.

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Authors and Affiliations

  1. Cardiovascular Division, King’s College London BHF Centre of Excellence, The Rayne Institute, St Thomas’ Hospital, London, SE1 7EH, UK

    Rebecca L. Charles, Joseph R. Burgoyne & Philip Eaton

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  1. Rebecca L. Charles
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  2. Joseph R. Burgoyne
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  3. Philip Eaton
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Correspondence to Philip Eaton .

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Editors and Affiliations

  1. Physiologisches Institut, Universität Gießen, Aulweg 129, Gießen, 35392, Germany

    Heinrich Sauer

  2. James Black Centre, King's College, London, Coldharbour Lane 125, London, SE5 9NU, United Kingdom

    Ajay M. Shah

  3. Fac. Medicina, Instituto do Coração (INCOR), Universidade de São Paulo, Av. Enéas de Carvalho Aguiar 44, São Paulo, 05403-000, São Paulo, Brazil

    Francisco R. M. Laurindo

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Charles, R.L., Burgoyne, J.R., Eaton, P. (2010). Mechanisms of Redox Signaling in Cardiovascular Disease. In: Sauer, H., Shah, A., Laurindo, F. (eds) Studies on Cardiovascular Disorders. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-600-9_2

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