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Oxidative Stress in Cardiac Transplantation

  • Galen M. Pieper
  • Ashwani K. Khanna
Chapter
Part of the Oxidative Stress in Applied Basic Research and Clinical Practice book series (OXISTRESS)

Abstract

Early experimental studies which measured antioxidant defenses and accumulation of lipid peroxidation products suggested that oxidative stress plays a role in cardiac transplant rejection. This led to studies designed to test the efficacy of intervention with antioxidants in experimental and clinical cardiac transplantation. This chapter focuses on the critical evidence (both indirect and direct) for oxidative stress. The review considers how oxidative stress may be increased as a consequence of the various facets of transplantation. These include the contributions of organ preservation, ischemia-reperfusion injury, rejection, and the superimposition of immunosuppressant therapy. It is acknowledged that each of these components may combine to contribute to the overall concept of increased oxidative stress in cardiac transplant recipients.

Keywords

Transplantation Rejection Organ preservation Immunosuppressant Apoptosis 

Notes

Acknowledgments

This research was supported, in part, by National Institutes of Health, Heart and Lung Institute Grant #HL078937.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Division of Transplant Surgery, Department of SurgeryMedical College of Wisconsin, Cardiovascular Research Center and the Free Radical Research CenterMilwaukeeUSA
  2. 2.Division of Cardiology, Department of MedicineUniversity of MarylandBaltimoreUSA

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