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The Treatment of Adult Acute Lymphoblastic Leukemia (ALL): Risk Stratification and Strategies

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Leukemia and Related Disorders

Part of the book series: Contemporary Hematology ((CH))

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Abstract

Acute lymphoblastic leukemia (ALL) is a highly aggressive neoplasm of precursor cells (lymphoblasts) committed to the lymphoid B-cell or T-cell lineage. It is significantly more prevalent in children, representing nearly 25% of all childhood cancers, but accounting for only 1% of all adult malignancies. The peak prevalence of ALL falls between the ages of 2 and 5 years, and 75% of all cases occur in children under the age of 6 years. The estimated number of new cases in the United States in 2008 was approximately 5,400, and 1,460 people died of their disease.

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  1. Division of Hematology, University of Washington School of Medicine, 825 Eastlake Ave E, Seattle, WA, 98109, USA

    Andrei R. Shustov M.D.

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  1. Univ of Washington School of Medicine, Member,, Professor of Med, Division of Hematology, Attending Physician, Seattle Cancer Care Alliance, Seattle, 98109-1024, Washington, USA

    Elihu H. Estey

  2. Director, Clinical Research Division,, Fred Hutchinson Cancer Research Center, Professor of Medicine; Head of Oncology, Seattle Cancer Care Alliance, Univ of Washington Sch of Med, Seattle, 98109-1024, Washington, USA

    Fred R. Appelbaum

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Shustov, A.R. (2012). The Treatment of Adult Acute Lymphoblastic Leukemia (ALL): Risk Stratification and Strategies. In: Estey, E., Appelbaum, F. (eds) Leukemia and Related Disorders. Contemporary Hematology. Springer, New York, NY. https://doi.org/10.1007/978-1-60761-565-1_2

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