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Gastroparesis pp 379–389Cite as

Endoscopic Full-Thickness Gastric Biopsy for Evaluation of Patients

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Part of the book series: Clinical Gastroenterology ((CG))

Abstract

A significant proportion of patients with gastroparesis do not respond adequately to standard medical treatment and gastric electric stimulation (GES). Loss of interstitial cells of Cajal (ICCs) on full-thickness gastric biopsies has been shown to be a predictor of poor response to GES. Full-thickness gastric biopsies may help diagnose severe depletion of ICCs and/or other specific gastric abnormalities, which hopefully will guide diagnosis and specific individualized and targeted therapies. Recent advances in endoscopic techniques have allowed the development of novel methods to obtain full-thickness gastric biopsies. Further refinement of these techniques is needed to improve their safety and applicability.

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Author information

Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA

    Rukshana N. Cader MB, BCh, BAO (Fellow in Gastroenterology) & Mouen A. Khashab MD (Assistant Professor of Medicine, Director of Therapeutic Endoscopy)

  2. Division of Gastroenterology and Hepatology, Department of Medicine, The Johns Hopkins Hospital, 600 N. Wolfe Street, Blalock 465, Baltimore, MD, 21287, USA

    Anthony N. Kalloo MD (The Moses and Helen Golden Paulson Professor of Gastroenterology)

Authors
  1. Rukshana N. Cader MB, BCh, BAO
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  2. Mouen A. Khashab MD
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  3. Anthony N. Kalloo MD
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Corresponding author

Correspondence to Anthony N. Kalloo MD .

Editor information

Editors and Affiliations

  1. School of Medicine, Department of Medicine, Temple University, N. Broad St. 3401, Philadelphia, 19140, Pennsylvania, USA

    Henry P. Parkman

  2. Paul L Foster School of Medicine, Department of Internal Medicine, Texas Tech University Health Sciences Ce, Alberta Avenue 4800, El Paso, 77905, Texas, USA

    Richard W. McCallum

Additional information

Conflicts of Interest:

Rukshana Cader has no conflicts of interest to disclose. Mouen Khashab has no conflicts of interest to disclose. Anthony Kalloo is a founding Member, equity Holder and consultant for Apollo Endosurgery.

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© 2012 Springer Science+Business Media, LLC

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Cader, R.N., Khashab, M.A., Kalloo, A.N. (2012). Endoscopic Full-Thickness Gastric Biopsy for Evaluation of Patients. In: Parkman, H., McCallum, R. (eds) Gastroparesis. Clinical Gastroenterology. Humana Press. https://doi.org/10.1007/978-1-60761-552-1_31

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  • DOI: https://doi.org/10.1007/978-1-60761-552-1_31

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-551-4

  • Online ISBN: 978-1-60761-552-1

  • eBook Packages: MedicineMedicine (R0)

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