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PKC and the Control of Apoptosis

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Book cover Protein Kinase C in Cancer Signaling and Therapy

Part of the book series: Current Cancer Research ((CUCR))

Abstract

Cells respond to a wide range of cellular toxins by inducing a suicide pathway known as apoptosis. Apoptosis plays a critical role in development, tissue remodeling, and in the removal of damaged and genetically altered cells. Activation of cell death pathways must be tightly regulated as too much or too little apoptosis can have drastic consequences for tissue homeostasis and for disease initiation and progression. While the mechanism of how apoptosis is executed has been extensively studied, little is known about how other signaling pathways influence the decision to die. In this regard, members of the protein kinase C (PKC) family of serine/threonine protein kinases are emerging as important modulators of the apoptotic response. Here we will discuss the role of specific PKC isoforms in regulating cell death, and address how alterations in the expression or activity of some of these kinases contribute to human diseases.

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Authors and Affiliations

  1. Department of Craniofacial Biology, School of Dental Medicine, Anschutz Medical Campus, University of Colorado Denver, 13001 E 17th Place, Aurora, CO, 80045, USA

    Mary E. Reyland

  2. The Department of Obstetrics and Gynecology, School of Medicine, Anschutz Medical Campus, University of Colorado Denver, 13001 E 17th Place, Aurora, CO, 80045, USA

    Andrew P. Bradford

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  1. Mary E. Reyland
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  2. Andrew P. Bradford
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Correspondence to Mary E. Reyland .

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  1. School of Medicine, University of Pennsylvania, Curie Boulevard 421, Philadeliphia, 19147, USA

    Marcelo G. Kazanietz

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Reyland, M.E., Bradford, A.P. (2010). PKC and the Control of Apoptosis. In: Kazanietz, M. (eds) Protein Kinase C in Cancer Signaling and Therapy. Current Cancer Research. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-543-9_9

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  • DOI: https://doi.org/10.1007/978-1-60761-543-9_9

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