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Eosinophilic Esophagitis pp 83–96Cite as

Esophageal Remodeling in Eosinophilic Esophagitis

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Part of the book series: Clinical Gastroenterology ((CG))

Abstract

The normal esophagus is composed of layers from the lumen to the adventitia. The non-keratinized stratified squamous epithelium abuts the lumen while the subepithelial regions contain the underlying lamina propria, muscularis mucosa, submucosa, and muscularis propria. The esophageal epithelium contains regenerative cells in the basal zone, which usually comprises 15% of the total epithelial height while projections of lamina propria, known as the vascular papillae, extend to approximately one third of the thickness of the squamous epithelium. In the normal esophagus, the LP comprises non-fibrotic, reticular collagen filaments and the epithelium is devoid of eosinophilic infiltration. Therefore, epithelial eosinophilia indicates a pathologic condition.

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Acknowledgements

The authors thank Dr. Robert Newbury for EE image. Author support from the Women in Allergy Junior Faculty Development Grant and NIH/NIAID R01AI092135 (SSA) and NIHT32 AI training grant to UCSD (LMT).(SSA) and NIH T32 Training grant (LT)

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Authors and Affiliations

  1. Allergy and Immunology, Department of Medicine, University of California, San Diego, CA, USA

    Louanne M. Tourangeau MD

  2. Division of Allergy, Immunology, Departments of Pediatrics and Medicine, University of California, Rady’s Children’s Hospital, San Diego, CA, USA

    Seema S. Aceves MD, PhD

Authors
  1. Louanne M. Tourangeau MD
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  2. Seema S. Aceves MD, PhD
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Corresponding author

Correspondence to Seema S. Aceves MD, PhD .

Editor information

Editors and Affiliations

  1. The Children’s Hospital of Philadelphia, Center for Pediatric Eosinophilic Disord, The Univeristy of Pennsylvania School of, 34th Street & Civic Center Blvd., Philadelphia, 19104, Pennsylvania, USA

    Chris A. Liacouras

  2. University Medical Center, Pediatric Gastroenterology and Nutrition, Greenville Hospital System, Patewood Drive 200, Greenville, 29615, South Carolina, USA

    Jonathan E. Markowitz

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Tourangeau, L.M., Aceves, S.S. (2012). Esophageal Remodeling in Eosinophilic Esophagitis. In: Liacouras, C., Markowitz, J. (eds) Eosinophilic Esophagitis. Clinical Gastroenterology. Humana Press. https://doi.org/10.1007/978-1-60761-515-6_6

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  • DOI: https://doi.org/10.1007/978-1-60761-515-6_6

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-514-9

  • Online ISBN: 978-1-60761-515-6

  • eBook Packages: MedicineMedicine (R0)

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