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Mitochondrial Regulation of Oxygen Sensing

Conference paper
First Online:
Part of the Advances in Experimental Medicine and Biology book series (volume 661)

Abstract

Hypoxia promotes physiological processes such as energy metabolism, angiogenesis, cell proliferation, and cell viability through the transcription factor Hypoxia Inducible Factor (HIF). Hypoxia also diminishes the activity of ATP consuming processes to promote cell survival. The mechanism(s) by which hypoxia activates HIF and diminishes ATP demand are a subject of intensive research. Here we outline the model in which mitochondrial complex III regulate the activity of HIF and diminish ATP utilization processes through the increased production of ROS during hypoxia.

Keywords

Mitochondria HIF ROS Na/K ATPase 
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Notes

Acknowledgments

This work was supported by NIH grant GM60472-09.

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© Humana Press, a part of Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Division of Pulmonary and Critical Care Medicine, Department of MedicineNorthwestern UniversityChicagoUSA

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