Through evolutionary history the primary mechanism by which the cells or tissues of most organisms sense their environment has been the heptahelical G protein–coupled receptor (GPCR). This prototypic receptive entity has its origins in the earliest forms of life and often comprises up to 5% of the genome of most unicellular and multicellular life forms. The GPCR system has adapted to perceive almost all forms of environmental entities, for example, photons, odorants, lipids, carbohydrates, peptides, and nucleic acids. The GPCR system has also likely adapted to the presence of exogenous compounds that may at some doses be deleterious but at lower levels may indeed possess beneficial actions. Therefore, with respect to the evolutionary pressure of diverse environments, it would be an extreme advantage for an organism to adapt multiple components of its primary receptive system to take advantage of any beneficial effects of agents present in harsh or damaging environments.
- Gprotein–coupled receptor
- Dose response
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Chadwick, W., Maudsley, S. (2010). The Devil is in the Dose: Complexity of Receptor Systems and Responses. In: Mattson, M., Calabrese, E. (eds) Hormesis. Humana Press. https://doi.org/10.1007/978-1-60761-495-1_5
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