Cancer and IgE pp 137-158 | Cite as

Mast Cells in Allergy and Tumor Disease

  • Anna Wasiuk
  • Victor C. de Vries
  • Elizabeth C. Nowak
  • Randolph J. NoelleEmail author


In allergy, mast cells (MCs) are known for the notoriously detrimental role they play. MC mediators like histamine, prostaglandins, leukotrienes and thromboxane are released during the early phase of an allergic reaction and produce inflammation and local tissue responses. One pervasive roadblock in the effective development of therapeutic immunity to cancer is the fact that tumors create immune privileged sites that are resistant to the development of effective inflammation and effective anti-tumor responses. In this chapter we will present the current knowledge of the inflammatory responses elicited in allergies by IgE and MCs as well as the current knowledge on how the responses of MCs may regulate tumor growth and the immune response to tumors.


Vascular Endothelial Growth Factor Mast Cell Atopic Dermatitis Helminth Infection Airway Smooth Muscle Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Anna Wasiuk
    • 1
  • Victor C. de Vries
    • 1
  • Elizabeth C. Nowak
    • 1
  • Randolph J. Noelle
    • 1
    Email author
  1. 1.Department of Microbiology and ImmunologyDartmouth Medical SchoolLebanonUSA

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