Epidemiological Evidence: IgE, Atopy, and Solid Tumors

  • Michelle C. TurnerEmail author


Epidemiological investigation into a potential relation between a history of allergic disorders, typically characterized by high levels of IgE, and cancer occurrence has been conducted for at least the past five decades. Recently, there is renewed interest in the field, and the literature is expanding rapidly. This chapter summarizes the epidemiological literature examining the potential relation between allergy and cancer, with a particular focus on the most recent contributions to the field. Although the majority of new and previously published studies evaluated self-reported history of specific allergic disorders (asthma, hay fever, eczema), there were also several new studies examining total or allergen-specific IgE antibodies, hospital discharges for allergic conditions, skin prick tested patients, and allergy-related gene polymorphisms in relation to cancer risk. Although there are a number of inverse relations reported, particularly with pancreatic cancer and glioma, there remain a number of methodological considerations. Further research is recommended in order to better understand the nature of a possible inverse relation and possible mechanisms of action with implications for cancer treatment and prevention. Multidisciplinary collaborations between the population and laboratory-based sciences would be particularly useful.


Atopic Dermatitis Standardize Incidence Ratio Acoustic Neuroma Allergic Disorder Significant Inverse Association 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Michelle C. Turner holds a Canada Graduate Scholarship from the Canadian Institutes of Health Research.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, Faculty of Graduate and Post-Graduate StudiesUniversity of OttawaOttawaCanada

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