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Cancer and IgE pp 231-254 | Cite as

The Targets of IgE: Allergen-Associated and Tumor-Associated Molecular Patterns

  • Erika Jensen-JarolimEmail author
  • Diana Mechtcheriakova
  • Isabella Pali-Schoell
Chapter

Abstract

The most studied targets of IgE immunoglobulins are termed allergens and mostly represent protein antigens from plant or animal origin. However, it has been revealed that also pathogens and self-antigens can be recognized by IgE. Thus, besides a detrimental role in allergy, IgE may exert defense and surveillance functions. Here, we discuss the display of rigid epitope patterns as a common key feature of antigens leading to both formation of high-affinity IgE antibodies by B lymphocytes and IgE-mediated triggering of effector cells. In analogy to the principle of pathogen-associated patterns as danger signals, we introduce here the terms allergen-associated molecular patterns (AAMPs) for the repetitive epitopes exposed by allergens and tumor-associated molecular patterns (TAMPs) in settings when molecular epitope patterns are displayed through overexpressed tumor antigens.

Keywords

Epidermal Growth Factor Receptor Lipid Raft Epidermal Growth Factor Receptor Family Tumor Cell Membrane Epitope Density 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was supported by grants of the Austrian Science Fund FWF (P18238-B13, SFB F01808-B13) and by the Ludwig Boltzmann Cluster Oncology, Vienna, Austria. Isabella Pali-Schoell was supported by Herta Firnberg grant T283-B13 of the FWF. Further, we would like to thank Mr. Walter Jarolim, crossip comm, Vienna, Austria, for excellent support in graphic arts.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Erika Jensen-Jarolim
    • 1
    Email author
  • Diana Mechtcheriakova
    • 1
  • Isabella Pali-Schoell
    • 1
  1. 1.IPP – Department of Pathophysiology, Center of Pathophysiology, Infectiology and ImmunologyMedical University ViennaViennaAustria

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