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Dyslipidemias pp 137-154 | Cite as

Dyslipidemia in Chronic Kidney Disease and Nephrotic Syndrome

  • Nosratola D. VaziriEmail author
Chapter
Part of the Contemporary Endocrinology book series (COE)

Abstract

The prevailing pandemic of type 2 diabetes and hypertension has led to a dramatic rise in the incidence of chronic kidney disease worldwide. Chronic kidney disease and proteinuria are associated with cardiovascular disease and profound alteration of lipid metabolism and serum lipid and lipoprotein profile. The associated lipid disorders play a major role in progression of renal and cardiovascular disease in this population. The nature and mechanisms of lipid abnormalities in kidney disease vary depending on the presence and severity of proteinuria, renal failure, renal replacement modalities (hemodialysis, peritoneal dialysis, and renal transplantation), dietary and drug regimens, and preexistent genetic disorders of lipid metabolism.

Keywords

Inflammation Cardiovascular disease Progression of kidney disease Hemodialysis Peritoneal dialysis Nephrotic syndrome Proteinuria Renal transplantation Atherosclerosis Statins 

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© Humana Press 2015

Authors and Affiliations

  1. 1.Division of Nephrology and HypertensionUniversity of California Irvine Medical Center, MedicineOrangeUSA

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