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Amyloid and Related Disorders pp 81–103Cite as

Localized Amyloidoses and Amyloidoses Associated with Aging Outside the Central Nervous System

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Part of the book series: Current Clinical Pathology ((CCPATH))

Abstract

The localized amyloid forms constitute a heterogeneous group of lesions, appearing in a large number of tissues and generally with an obscure pathogenesis. Many of them are clearly associated with aging and are sometimes classified as “senile” forms. Some, including Aβ and AIAPP amyloid, in the brain and islets of Langerhans, respectively, are associated with specific diseases and believed to participate in their pathogenesis. For many others is the impact unclear. The localized amyloids, with very few exceptions, have that in common that the fibril protein is expressed close to the site of deposition. The biochemical nature is highly divergent, but for each form there is one specific protein. In practical surgical pathology the most common problem is associated with localized AL amyloidosis due to the importance to exclude the possibility of systemic disease. In addition to the strictly localized amyloid forms, this chapter also deals with senile systemic amyloidosis, derived from wild-type transthyretin and particularly affecting the heart.

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Acknowledgments

Own research was supported by the Swedish Research Council.

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  1. Rudbeck Laboratory, Departments of Immunology, Genetics and Pathology, Uppsala University, Uppsala, SE-751 85, Sweden

    Per Westermark M.D., Ph.D.

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  1. Per Westermark M.D., Ph.D.
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Correspondence to Per Westermark M.D., Ph.D. .

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  1. Bldg#110, Rm#2242, Department of Pathology, Loyola University Medical Center, S. First Avenue 2160, Maywood, 60153, Illinois, USA

    Maria M. Picken MD, PhD, FASN

  2. , Department of Laboratory Medicine and Pa, Mayo Clinic, First Street SW 200, Rochester, 55905, USA

    Ahmet Dogan, M.D., Ph.D.

  3. , Department of Renal Pathology, Bostwick Laboratories, Lake Ellenor Dr. 8001, Orlando, 32809, Florida, USA

    Guillermo A. Herrera, M.D.

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Westermark, P. (2012). Localized Amyloidoses and Amyloidoses Associated with Aging Outside the Central Nervous System. In: Picken MD, PhD, FASN, M., Dogan, M.D., Ph.D., A., Herrera, M.D., G. (eds) Amyloid and Related Disorders. Current Clinical Pathology. Humana Press. https://doi.org/10.1007/978-1-60761-389-3_6

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