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Interrelationships Between Paraoxonase-1 and Monocyte Chemoattractant Protein-1 in the Regulation of Hepatic Inflammation

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Book cover Paraoxonases in Inflammation, Infection, and Toxicology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 660))

Abstract

Oxidative stress and inflammation play a central role in the onset and development of liver diseases irrespective of the agent causing the hepatic impairment. The monocyte chemoattractant protein-1 is intimately involved in the inflammatory reaction and is directly correlated with the degree of hepatic inflammation in patients with chronic liver disease. Recent studies showed that hepatic paraoxonase-1 may counteract the production of the monocyte chemoattractant protein-1, thus playing an anti-inflammatory role. The current review summarises experiments suggesting how paraoxonase-1 activity and expression are altered in liver diseases, and their relationships with the monocyte chemoattractant protein-1 and inflammation.

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Abbreviations

ABCA1:

ATP-binding cassette transporter 1

ALD:

alcoholic liver disease

CAM:

cell adhesion molecules

HCV:

hepatitis C virus

HDL:

high-density lipoproteins

LDL:

low-density lipoproteins

MCP-1:

monocyte chemoattractant protein-1

NAFLD:

non-alcoholic fatty liver disease

NASH:

non-alcoholic steatohepatitis

PON1:

paraoxonase-1

PPAR:

peroxisome proliferator-activated receptor

ROS:

reactive oxygen species

TBBL:

5-thiobutyl butyrolactone

References

  • Abdallah MY, Ahmad IM, Spitz DR et al. (2005) Hepatitis C virus-core and non structural proteins lead to different effects on cellular antioxidant defenses. J Med Virol 76:489–497

    Article  Google Scholar 

  • Afford SC, Fischer NC, Neil DAH et al. (1998) Distinct patterns of chemokine expression are associated with leukocyte recruitment in alcoholic hepatitis and alcoholic cirrhosis. J Pathol 186:82–89

    Article  CAS  PubMed  Google Scholar 

  • Albano E (2006) Alcohol, oxidative stress and free radical damage. Proc Nutr Soc 65:278–290

    Article  CAS  PubMed  Google Scholar 

  • Albano E (2008) Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Mol Aspects Med 29:9–16

    Article  CAS  PubMed  Google Scholar 

  • Aleffi S, Petrai I, Bertolani C et al. (2005) Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells. Hepatology 42:1339–1348

    Article  CAS  PubMed  Google Scholar 

  • Aviram M, Rosenblat M, Billecke S et al. (1999) Human serum paraoxonase (PON1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants. Free Rad Biol Med 26:892–904

    Article  CAS  PubMed  Google Scholar 

  • Aviram M, Hardak E, Vaya J et al. (2000) Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary and carotid atherosclerotic lesions. PON1 esterase and peroxidase-like activities. Circulation 101:2510–2517

    CAS  PubMed  Google Scholar 

  • Batey RG, Cao Q, Gould B (2002) Lymphocyte-mediated liver injury in alcohol-related hepatitis. Alcohol 27:37–41

    Article  CAS  PubMed  Google Scholar 

  • Birjmohun RS, Van Leuven SI, Levels JHM et al. (2007) High-density lipoprotein attenuates inflammation and coagulation on endotoxin challenge in humans. Arterioscler Thromb Vasc Biol 27:1153–1158

    Article  CAS  PubMed  Google Scholar 

  • Burlina A, Galzigna L (1974) Serum arylesterase isoenzymes in chronic hepatitis. Clin Biochem 7:202–205

    Article  CAS  PubMed  Google Scholar 

  • Burlina A, Michielin E, Galzigna L (1977) Characteristics and behaviour of arylesterase in human serum and liver. Eur J Clin Inves 7:17–20

    Article  CAS  Google Scholar 

  • Cabré M, Ferré N, Folch J et al. (1999) Inhibition of hepatic cell nuclear DNA fragmentation by zinc in carbon tetrachloride-treated rats. J Hepatol 31:228–234

    Article  PubMed  Google Scholar 

  • Calabresi L, Gomaraschi M, Vilia B et al. (2002) Elevated soluble adhesion molecules in subjects with low HDL-cholesterol. Arterioscler Thromb Vasc Biol 22:656–661

    Article  CAS  PubMed  Google Scholar 

  • Camps J, Marsillach J, Joven J (2007) Measurement of serum paraoxonase-1 activity as a potential biomarker for chronic liver impairment. Clin Chim Acta 386:114–115

    Article  CAS  PubMed  Google Scholar 

  • Chittury S, Farrell GC (2001) Ethiopathogenesis of nonalcoholic steatohepatitis. Semin Liver Dis 21:27–41

    Article  Google Scholar 

  • Choi J, Lee KJ, Zheng Y et al. (2004) Reactive oxygen species suppress hepatitis C virus RNA replication in human hepatoma cells. Hepatology 39:81–89

    Article  CAS  PubMed  Google Scholar 

  • Choi J, Ou JHJ (2006) Mechanisms of liver injury. III. Oxidative stress in the pathogenesis of hepatitis C virus. Am J Physiol Gastrointest Liver Physiol 290:G847–G851

    Article  CAS  PubMed  Google Scholar 

  • Clay MA, Pyle DH, Rye KA et al. (2001) Time sequence of inhibition of endothelial adhesion molecule expression by reconstituted high density lipoproteins. Atherosclerosis 157:23–29

    Article  CAS  PubMed  Google Scholar 

  • Cockerill GW, Rye KA, Gamble JR et al. (1995) High density lipoproteins inhibit cytokine induced expression of endothelial cell adhesion molecules. Arterioscler Thromb Vasc Biol 15:1987–1994

    CAS  PubMed  Google Scholar 

  • Costa LG, Vitalone A, Cole TB et al. (2005) Modulation of paraoxonase (PON1) activity. Biochem Pharmacol 69:541–550

    Article  CAS  PubMed  Google Scholar 

  • Crabb DW, Liangpunsakul S (2006) Alcohol and lipid metabolism. J Gastroenterol Hepatol 21:S56–S60

    Article  CAS  PubMed  Google Scholar 

  • Day CP (2006) Genes or environment to determine alcoholic liver disease and non-alcoholic fatty liver disease. Liver Int 26:1021–1028

    Article  CAS  PubMed  Google Scholar 

  • Deakin S, Leviev I, Gomaraschi M et al. (2002) Enzymatically active paraoxonase-1 is located at the external membrane of producing cells and released by a high affinity, saturable, desorption mechanism. J Biol Chem 277:4301–4308

    Article  CAS  PubMed  Google Scholar 

  • Deakin S, Leviev I, Brulhart-Meynet MC et al. (2003) Paraoxonase-1 promoter haplotypes and serum paraoxonase: a predominant rele for polymorphic position –107, implicating the Sp1 transcription factor. Biochem J 372:643–649

    Article  CAS  PubMed  Google Scholar 

  • Devalaraja MN, McClain CJ,Barve S et al. (1999) Increased monocyte MCP-1 production in acute alcoholic hepatitis. Cytokine 11:875–881

    Article  CAS  PubMed  Google Scholar 

  • Ferré N, Camps J, Cabré M et al. (2001) Hepatic paraoxonase activity alterations and free radical production in rats with experimental cirrhosis. Metabolism 50:997–1000

    Article  PubMed  Google Scholar 

  • Ferré N, Camps J, Prats E et al. (2002) Serum paraoxonase activity: a new additional test for the improved evaluation of chronic liver damage. Clin Chem 48:261–268

    PubMed  Google Scholar 

  • Ferré N, Marsillach J, Camps J et al. (2005) Genetic association of paraoxonase-1 polymorphisms and chronic hepatitis C virus infection. Clin Chim Acta 361:206–210

    Article  PubMed  Google Scholar 

  • Ferré N, Marsillach J, Camps J et al. (2006). Paraoxonase-1 is associated with oxidative stress, fibrosis and FAS expression in chronic liver diseases. J Hepatol 45:51–59

    Article  PubMed  Google Scholar 

  • Fisher NC, Neil DAH, Williams A et al. (1999) Serum concentrations and peripheral secretion of the beta chemokines monocyte chemoattractant protein 1and macrophage inflammatory protein 1α in alcoholic liver disease. Gut 45:426–430

    Article  Google Scholar 

  • Forman HJ, Torres M, Fukuto J (2003) Signal transduction by reactive oxygen and nitrogen species: pathways and chemical principles. Kluwer Academic, Boston

    Google Scholar 

  • Fromenty B, Grimbert S, Mansouri A et al. (1995) Hepatic mitochondrial DNA deletion in alcoholics: association with microvesicular steatosis. Gastroenterology 108:193–200

    Article  CAS  PubMed  Google Scholar 

  • Fürnsinn C, Willson TM, Brunmair B (2007) Peroxisome proliferator-activated receptor-δ, a regulator of oxidative capacity, fuel switching and cholesterol transport. Diabetologia 50:8–17

    Article  PubMed  Google Scholar 

  • James RW, Deakin SP (2004) The importance of high-density lipoproteins for paraoxonase-1 secretion, stability, and activity. Free Rad Biol Med 37:1986–1994

    Article  CAS  PubMed  Google Scholar 

  • Jiang Y, Beller DI, Frendl G et al. (1992) Monocyte chemoattractant protein-1regulates adhesion molecule expression and cytokine production in human monocytes J Immunol 148:2423–2428

    CAS  PubMed  Google Scholar 

  • Kawai H, Sakamoto F, Inoue Y (1990) Improved specific assay for serum arylesterase using a water-soluble substrate. Clin Chim Acta 188:177–182

    Article  CAS  PubMed  Google Scholar 

  • Kharbanda KK, McVicker DL, Zetterman RK et al. (1995) Ethanol consumption reduces the proteolytic capacity and protease activities of hepatic lysosomes. Biochem Biophys Acta 1245:421–429

    PubMed  Google Scholar 

  • Kilic SS, Aydin S, Kilic N et al. (2005) Serum arylesterase and paraoxonase activity in patients with chronic hepatitis. World J Gastroenterol 11:7351–7354

    CAS  PubMed  Google Scholar 

  • Kleiner DE, Brunt EM, Natta MV et al. (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41:1313–1321

    Article  PubMed  Google Scholar 

  • Mackness B, Hine D, Liu Y et al. (2004) Paraoxonase-1 inhibits oxidised LDL-induced MCP-1 production by endothelial cells. Biochem Biophys Res Commun 318:680–683

    Article  CAS  PubMed  Google Scholar 

  • Mahmood S, Kawanaka M, Kamei A et al. (2004) Immunohistochemical evaluation of oxidative stress markers in chronic hepatitis C. Antioxid Redox Signal 6:19–24

    Article  CAS  PubMed  Google Scholar 

  • Marsillach J, Bertran N, Camps J et al. (2005) The role of circulating monocyte chemoattractant protein-1 as a marker of hepatic inflammation in patients with chronic liver disease. Clin Biochem 38:1138–1140

    Article  CAS  PubMed  Google Scholar 

  • Marsillach J, Ferré N, Vila MC et al. (2007) Serum paraoxonase-1 in chronic alcoholics: Relationship with liver disease. Clin Biochem 40:645–650

    Article  CAS  PubMed  Google Scholar 

  • Marsillach J, Aragonès G, Beltrán R et al. (2008) The measurement of the lactonase activity of paraoxonase-1 in the clinical evaluation of patients with chronic liver impairment. Clin Biochem doi:10.1016/j.clinbiochem.2008.09.120

    Google Scholar 

  • Marsillach J, Camps J, Ferré N et al. (2009) Paraoxonase-1 is related to inflammation, fibrosis and PPARδ in experimental liver disease. BMC Gastroenterol 9:3

    Google Scholar 

  • Mottaran E, Stewart SF, Rolla R et al. (2002) Lipid peroxidation contributes to immune reactions associated with alcoholic liver disease. Free Rad Biol Med 32:38–48

    Article  CAS  PubMed  Google Scholar 

  • Nanji AA (2004) Role of different dietary fatty acids in the pathogenesis of experimental alcoholic liver disease. Alcohol 34:21–25

    Article  CAS  PubMed  Google Scholar 

  • Navab M, Imes SS. Hama SY et al. (1991) Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein. J Clin Invest 88:2039–2046

    Article  CAS  PubMed  Google Scholar 

  • Navab M, Hama SY, Cooke CJ et al. (2000a) Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: step 1. J Lip Res 41:1481–1484

    CAS  Google Scholar 

  • Navab M, Hama SY, Anantharamaiah GM et al. (2000b) Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3. J Lip Res 41:1485–1508

    Google Scholar 

  • Navab M, Berliner JA, Subbanagounder G et al. (2001) HDL and the inflammatory response induced by LDL-derived oxidised phospholipids. Arterioscler Thromb Vasc Biol 21:481–488

    CAS  PubMed  Google Scholar 

  • Navab M, Ananthramaiah GM, Reddy ST et al. (2004) The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL. J Lip Res 45:993–1007.

    Article  CAS  Google Scholar 

  • Negre-Salvayre A, Dousset N, Ferretti G et al. (2006) Antioxidant and cytoprotective properties of high-density lipoproteins in vascular cells. Free Rad Biol Med 41:1031–1040

    Article  CAS  PubMed  Google Scholar 

  • Nieto N (2007) Ethanol and fish oil induce NFkB transactivation of the collagen a2(1) promoter through lipid peroxidation-driven activation of PKC-PI3K-Akt pathway. Hepatology 45:1433–1445

    Article  CAS  PubMed  Google Scholar 

  • Nofer JR, Kehrel B, Fobker M et al. (2002) HDL and arteriosclerosis: beyond reverse cholesterol transport. Atherosclerosis 161:1–16

    Article  CAS  PubMed  Google Scholar 

  • Pan M, Cederbaum AI, Zhang YL et al. (2004) Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production. J Clin Invest 113:1277–1287

    CAS  PubMed  Google Scholar 

  • Parola M, Bellomo G, Robino G et al. (1999) 4-Hydroxynonenal as a biological signal: molecular basis and pathophysiological implications. Antioxidant Redox Signaling 1:255–284

    Article  CAS  Google Scholar 

  • Pesant M, Sueur S, Dutartre P et al. (2006) Peroxisome proliferator-activated receptor δ (PPARδ) activation protects H9c2 cardiomyoblasts from oxidative stress-induced apoptosis. Cardiovasc Res 69:440–449

    Article  CAS  PubMed  Google Scholar 

  • Pessayre D, Fromenty B (2005) NASH a mitochondrial disease. J Hepatol 42:928–940

    Article  CAS  PubMed  Google Scholar 

  • Rao MN, Marmillot P, Gong M et al. (2003) Light, but not heavy alcohol drinking, stimulates paraoxonase by upregulating liver mRNA in rats and humans. Metabolism 52:1287–1294

    Article  CAS  PubMed  Google Scholar 

  • Simpson KJ, Henderson NC, Bone-Larson CL et al. (2003) Chemokines in the pathogenesis of liver disease: so many players with poorly defined roles. Clin Sci (Lond) 104:47–63

    Article  CAS  Google Scholar 

  • Solís Herruzo JA, García Ruíz I, Pérez Carreras M et al. (2006) Non-alcoholic fatty liver disease. from insulin resistance to mitochondrial dysfunction. Rev Esp Enferm Dig (Madrid) 98:844–874

    Google Scholar 

  • Sugano M, Tsuchida K, Makino N (2000) High-density lipoproteins protect endothelial cells from tumor necrosis factor-a-induced apoptosis. Biochem Biophys Res Commun 272:872–876

    Article  CAS  PubMed  Google Scholar 

  • Tamura Y, Sugimoto M, Muruyama T et al. (2008) Inhibition of CCR2 ameliorates insulin resistance and hepatic steatosis in db/db mice. Arterioscler Thromb Vasc Biol doi:10.1161/ATVBAHA.108.168633

    Google Scholar 

  • Tardif KD, Waris G, Siddiqui A (2005) Hepatitis C virus, ER stress, and oxidative stress. Trends Microbiol 13:159–163

    Article  CAS  PubMed  Google Scholar 

  • Thiele GM, Freeman TK, Klassen LW (2004) Immunological mechanisms of alcoholic liver disease. Semin Liver Dis 24:273–287

    Article  CAS  PubMed  Google Scholar 

  • Thoren F, Romero A, Lindh M et al. (2004) A hepatitis C virus-encoded, nonstructural protein (NS3) triggers dysfunction and apoptosis in lymphocytes: role of NADPH oxidase-derived oxygen radicals. J Leukoc Biol 76:1180–1186

    Article  CAS  PubMed  Google Scholar 

  • Tous M, Ferré N, Rull A et al (2006) Dietary cholesterol and differential monocyte chemoattractant protein-1 gene expression in aorta and liver of apo E-deficient mice Biochem Biophys Res Commun 340:1078–1084

    Article  CAS  PubMed  Google Scholar 

  • Tsukamoto H, Lu SC (2001) Current concepts in the pathogenesis of alcoholic liver injury. FASEB J 15:1335–1349

    Article  CAS  PubMed  Google Scholar 

  • Tsuruta S, Nakamuta M, Enjoji M et al. (2004) Anti-monocyte chemoattractant protein-1 gene therapy prevents dimethylnitrosamine-induced hepatic fibrosis in rats. Int J Mol Med 14:837–842

    CAS  PubMed  Google Scholar 

  • Younossi ZM, Diehl AM, Ong JP (2002) Nonalcoholic fatty liver disease: An agenda for clinical research. Hepatology 35:746–752

    Article  PubMed  Google Scholar 

  • Xu GY, Lv GC, Chen Y et al. (2005) Monitoring the level of serum paraoxonase 1 activity in liver transplantation patients. Hepatobiliary Pancreat Dis Int 4:178–181

    CAS  PubMed  Google Scholar 

  • Zamara E, Novo E, Marra F et al. (2004) 4-Hydroxynonenal as a selective pro-fibrogenic stimulus for activated human hepatic stellate cells. J Hepatol 40:60–68

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

Some studies described in this article have been funded by grants from the Instituto de Salud Carlos III (FIS 02/0430, 04/1752, 05/1607, RCMN C03/08 and RD06), Ministerio de Sanidad, Madrid, Spain. J. M. is the recipient of a post-graduate fellowship from the Generalitat de Catalunya (FI 05/00068).

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Authors and Affiliations

  1. Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, C. Sant Joan s/n, 43201-Reus, Catalunya, Spain

    Jordi Camps

  2. Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Catalunya, Spain

    Judit Marsillach, Anna Rull, Carlos Alonso-Villaverde & Jorge Joven

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  1. Jordi Camps
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  2. Judit Marsillach
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  3. Anna Rull
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  4. Carlos Alonso-Villaverde
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  5. Jorge Joven
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Correspondence to Jordi Camps .

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  1. Division of Cardiology, University of California, Los Angeles, Le Conte Ave. 10833, Los Angeles, 90095-1679, U.S.A.

    Srinivasa T. Reddy

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Camps, J., Marsillach, J., Rull, A., Alonso-Villaverde, C., Joven, J. (2010). Interrelationships Between Paraoxonase-1 and Monocyte Chemoattractant Protein-1 in the Regulation of Hepatic Inflammation. In: Reddy, S. (eds) Paraoxonases in Inflammation, Infection, and Toxicology. Advances in Experimental Medicine and Biology, vol 660. Humana Press. https://doi.org/10.1007/978-1-60761-350-3_2

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