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Paraoxonases in Inflammation, Infection, and Toxicology pp 1–4Cite as

ApoE Mimetic Peptide Reduces Plasma Lipid Hydroperoxide Content with a Concomitant Increase in HDL Paraoxonase Activity

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 660))

Abstract

ApoE mimetic peptide possesses the putative receptor binding domain 141–150 (LRKLRKRLLR) of apoE covalently linked to the class A amphipathic helical peptide 18A. It dramatically reduces plasma cholesterol in dyslipidemic mouse and rabbit models. Recycling of apoE mimetic peptide increases the duration of preβ-HDL formation leading to extended anti-inflammatory and atheroprotective properties.

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References

  • Datta, G., M. Chaddha, D.W.Garber, B.H.Chung, E.M.Tytler, N. Dashti, W.A.Bradley, S.H.Gianturco, and G.M.Anantharamaiah. 2000. The receptor binding domain of apolipoprotein E, linked to a model class A amphipathic helix, enhances internalization and degradation of LDL by fibroblasts. Biochemistry 39: 213–220

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Author information

Authors and Affiliations

  1. Departments of Medicine, Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, 35294, USA

    Geeta Datta, Manjula Chaddha, Shaila P. Handattu, Mayakonda N. Palgunachari, Gaurav Nayyar, David W. Garber, Himanshu Gupta, C. Roger White & G.M. Anantharamaiah

Authors
  1. Geeta Datta
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  2. Manjula Chaddha
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  3. Shaila P. Handattu
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  4. Mayakonda N. Palgunachari
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  5. Gaurav Nayyar
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  6. David W. Garber
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  7. Himanshu Gupta
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  8. C. Roger White
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  9. G.M. Anantharamaiah
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Corresponding author

Correspondence to Geeta Datta .

Editor information

Editors and Affiliations

  1. Division of Cardiology, University of California, Los Angeles, Le Conte Ave. 10833, Los Angeles, 90095-1679, U.S.A.

    Srinivasa T. Reddy

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© 2010 Humana Press, a part of Springer Science+Business Media, LLC

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Cite this paper

Datta, G. et al. (2010). ApoE Mimetic Peptide Reduces Plasma Lipid Hydroperoxide Content with a Concomitant Increase in HDL Paraoxonase Activity. In: Reddy, S. (eds) Paraoxonases in Inflammation, Infection, and Toxicology. Advances in Experimental Medicine and Biology, vol 660. Humana Press. https://doi.org/10.1007/978-1-60761-350-3_1

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