Serum Sickness and Serum Sickness-Like Reaction

  • Neha Reshamwala
  • Massoud MahmoudiEmail author


Serum sickness is an immune complex reaction, hypersensitivity type III, to a protein, serum, or hapten. The manifestations are based on antibody–antigen complexes developing 1–3 weeks postexposure to the antigen, but sooner upon reexposure, with the presentation of a multitude of symptoms (J Microbiol Immunol Infect 34:220–223, 2001). Other similar conditions can mimic or ­overlap the diagnosis and characteristics of serum sickness. Here, we present two ­challenging cases of serum sickness and serum sickness-like reaction.


Serum sickness Serum sickness-like reaction Immune complexes Hypersensitivity reaction 


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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.El Camino Hospital, Los GatosLos GatosUSA
  2. 2.Department of MedicineUniversity of California, San FranciscoSan FranciscoUSA

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