Serum sickness is an immune complex reaction, hypersensitivity type III, to a protein, serum, or hapten. The manifestations are based on antibody–antigen complexes developing 1–3 weeks postexposure to the antigen, but sooner upon reexposure, with the presentation of a multitude of symptoms (J Microbiol Immunol Infect 34:220–223, 2001). Other similar conditions can mimic or overlap the diagnosis and characteristics of serum sickness. Here, we present two challenging cases of serum sickness and serum sickness-like reaction.
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