Advertisement

Cold Urticaria

  • Grace Peace YuEmail author
  • Alan A. Wanderer
  • Massoud Mahmoudi
Chapter

Abstract

Cold urticaria is a physical urticaria in which patients experience ­urticaria, angioedema, or both in response to direct contact with cold environments, the ingestion of cold beverages or foods, and the handling of cold objects. In this chapter, we present two challenging cases of cold urticaria that highlight the diagnostic evaluation and treatment options for these patients.

Keywords

Urticaria Cold urticaria Cold stimulation time test 

References

  1. 1.
    Boyce JA. Successful treatment of cold-induced urticaria/anaphylaxis with anti-IgE. J Allergy Clin Immunol 2006; 117(6): 1415–8.PubMedCrossRefGoogle Scholar
  2. 2.
    Wanderer AA, Hoffman HM. The spectrum of acquired and familial cold-induced urticaria/urticaria-like syndromes. Immunol Allergy Clin North Am 2004; 24(2): 259–86, vii.PubMedCrossRefGoogle Scholar
  3. 3.
    Lemanske RF Jr., Bush RK. Cold urticaria in infectious mononucleosis. JAMA 1982; 247(11): 1604.PubMedCrossRefGoogle Scholar
  4. 4.
    Anderson RH. Cold urticaria with infectious mononucleosis: case report. Va Med 1983; 110(9): 549–50.PubMedGoogle Scholar
  5. 5.
    Mahmoudi M, Naguwa S. Cold-induced urticaria associated with hypothyroidism. J Am Osteopath Assoc 1999; 99(8): 394.PubMedGoogle Scholar
  6. 6.
    Gandhi C, Healy C, Wanderer AA, Hoffman HM. Familial atypical cold urticaria: description of a new hereditary disease. J Allergy Clin Immunol 2009; 124(6): 1245–50.PubMedCrossRefGoogle Scholar
  7. 7.
    Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet 2001; 29(3): 301–5.PubMedCrossRefGoogle Scholar
  8. 8.
    Soter NA, Joshi NP, Twarog FJ, Zeiger RS, Rothman PM, Colten HR. Delayed cold-induced urticaria: a dominantly inherited disorder. J Allergy Clin Immunol 1977; 59(4): 294–7.PubMedCrossRefGoogle Scholar
  9. 9.
    Hoffman HM, Wanderer AA, Broide DH. Familial cold autoinflammatory syndrome: phenotype and genotype of an autosomal dominant periodic fever. J Allergy Clin Immunol 2001; 108(4): 615–20.PubMedCrossRefGoogle Scholar
  10. 10.
    Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 2002; 10(2): 417–26.PubMedCrossRefGoogle Scholar
  11. 11.
    Hoffman HM. Therapy of autoinflammatory syndromes. J Allergy Clin Immunol 2009; 124(6): 1129–38; quiz 1139–40.PubMedCrossRefGoogle Scholar
  12. 12.
    Aksentijevich I, D Putnam C, Remmers EF, Mueller JL, Le J, Kolodner RD et al. The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model. Arthritis Rheum 2007; 56(4): 1273–85.PubMedCrossRefGoogle Scholar
  13. 13.
    Gruber BL, Baeza ML, Marchese MJ, Agnello V, Kaplan AP. Prevalence and functional role of anti-IgE autoantibodies in urticarial syndromes. J Invest Dermatol 1988; 90(2): 213–7.PubMedCrossRefGoogle Scholar
  14. 14.
    Kaplan AP, Garofalo J, Sigler R, Hauber T. Idiopathic cold urticaria: in vitro demonstration of histamine release upon challenge of skin biopsies. N Engl J Med 1981; 305(18): 1074–7.PubMedCrossRefGoogle Scholar
  15. 15.
    Keahey TM, Indrisano J, Kaliner MA. A case study on the induction of clinical tolerance in cold urticaria. J Allergy Clin Immunol 1988; 82(2): 256–61.PubMedCrossRefGoogle Scholar
  16. 16.
    Wanderer AA, Grandel KE, Wasserman SI, Farr RS. Clinical characteristics of cold-induced systemic reactions in acquired cold urticaria syndromes: recommendations for prevention of this complication and a proposal for a diagnostic classification of cold urticaria. J Allergy Clin Immunol 1986; 78(3 Pt 1): 417–23.PubMedCrossRefGoogle Scholar
  17. 17.
    Alangari AA, Twarog FJ, Shih MC, Schneider LC. Clinical features and anaphylaxis in children with cold urticaria. Pediatrics 2004; 113(4): e313–7.PubMedCrossRefGoogle Scholar
  18. 18.
    Mahmoudi M. Cold-induced urticaria. J Am Osteopath Assoc 2001; 101(5 Suppl): S1–4.PubMedGoogle Scholar
  19. 19.
    Wanderer AA. Hives: The Road to Diagnosis and Treatment of Urticaria. AnsonPublishing LLC, Bozeman; Montana 2007.Google Scholar
  20. 20.
    Siebenhaar F, Degener F, Zuberbier T, Martus P, Maurer M. High-dose desloratadine decreases wheal volume and improves cold provocation thresholds compared with standard-dose treatment in patients with acquired cold urticaria: a randomized, placebo-controlled, crossover study. J Allergy Clin Immunol 2009; 123(3): 672–9.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Grace Peace Yu
    • 1
    Email author
  • Alan A. Wanderer
  • Massoud Mahmoudi
  1. 1.Department of Pediatrics, Division of Allergy and ImmunologyStanford University School of MedicineStanfordUSA

Personalised recommendations