Cutaneous Lupus

  • Lisa G. Criscione-SchreiberEmail author


Rashes are among the most common manifestations of systemic lupus erythematosus (SLE), affecting up to 85% of individuals with SLE. Cutaneous lupus without systemic features is even more common than SLE. In many patients, cutaneous involvement can be widespread and debilitating, requiring systemic treatment. Here, two challenging cases of cutaneous lupus are described.


Cutaneous lupus Systemic lupus erythematosus Acute cutaneous lupus erythematosus Subacute cutaneous lupus erythematosus Bullous lupus 


  1. 1.
    Lin JH, Dutz JP, Sontheimer RD, Werth VP. Pathophysiology of cutaneous lupus erythematosus. Clin Rev Allergy Immunol. 2007;33(1–2):85–106.PubMedCrossRefGoogle Scholar
  2. 2.
    Vassileva S. Bullous systemic lupus erythematosus. Clin Dermatol. 2004;22(2):129–38.PubMedCrossRefGoogle Scholar
  3. 3.
    Patricio P, Ferreira C, Gomes MM, Filipe P. Autoimmune bullous dermatoses: a review. Ann N Y Acad Sci. 2009;1173:203–10.PubMedCrossRefGoogle Scholar
  4. 4.
    Horne NS, Narayan AR, Young RM, Frieri M. Toxic epidermal necrolysis in systemic lupus erythematosus. Autoimmun Rev. 2006;5(2):160–4.PubMedCrossRefGoogle Scholar
  5. 5.
    Paradela S, Martinez-Gomez W, Fernandez-Jorge B, Castineiras I, Yebra-Pimentel T, Llinares P, et al. Toxic epidermal necrolysis-like acute cutaneous lupus erythematosus. Lupus. 2007;16(9):741–5.PubMedCrossRefGoogle Scholar
  6. 6.
    Ting W, Stone MS, Racila D, Scofield RH, Sontheimer RD. Toxic epidermal necrolysis-like acute cutaneous lupus erythematosus and the spectrum of the acute syndrome of apoptotic pan-epidermolysis (ASAP): a case report, concept review and proposal for new classification of lupus erythematosus vesiculobullous skin lesions. Lupus. 2004;13(12):941–50.PubMedCrossRefGoogle Scholar
  7. 7.
    Faye O, Roujeau JC. Treatment of epidermal necrolysis with high-dose intravenous immunoglobulins (IV Ig): clinical experience to date. Drugs. 2005;65(15):2085–90.PubMedCrossRefGoogle Scholar
  8. 8.
    Baltaci M, Fritsch P. Histologic features of cutaneous lupus erythematosus. Autoimmun Rev. 2009;8(6):467–73.PubMedCrossRefGoogle Scholar
  9. 9.
    Kuhn A, Bijl M. Pathogenesis of cutaneous lupus erythematosus. Lupus. 2008;17(5):389–93.PubMedCrossRefGoogle Scholar
  10. 10.
    Kuhn A, Krammer PH, Kolb-Bachofen V. Pathophysiology of cutaneous lupus erythematosus–novel aspects. Rheumatology (Oxford). 2006;45 Suppl 3:iii14–6.Google Scholar
  11. 11.
    Srivastava M, Rencic A, Diglio G, Santana H, Bonitz P, Watson R, et al. Drug-induced, Ro/SSA-positive cutaneous lupus erythematosus. Arch Dermatol. 2003;139(1):45–9.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Division of Rheumatology and ImmunologyDuke UniversityDurhamUSA

Personalised recommendations