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The Diverse Roles of K + Channels in Brain Ischemia

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New Strategies in Stroke Intervention

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

K+-selective ion channels are important determinants of neuronal excitability. The activity of three particular K+ channels, Kir6.2, Slo1, and Kv2.1, is implicated in neuroprotection of ischemic brain neurons. Here we review recent studies on the molecular properties, expression, and function of these neuronal K+ channels, their regulation in ischemic neurons, and their potential as drug targets for prophylactic and/or post-event therapeutics.

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Acknowledgments

Work from our laboratories cited above was supported by NIH (NS34383 and NS42225) and AHA.

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Authors and Affiliations

  1. Department of Neural and Pain Sciences, Program in Neuroscience, Dental School, University of Maryland, 21201, Baltimore, MD, USA

    Hiroaki Misonou

  2. Department of Neurobiology, Physiology, and Behavior, College of Biological Sciences, School of Medicine, University of California, 95616, Davis, CA, USA

    James S. Trimmer

  3. Department of Physiology and Membrane Biology, School of Medicine, School of Medicine, University of California, 95616, Davis, CA, USA

    James S. Trimmer

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  1. Hiroaki Misonou
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Correspondence to Hiroaki Misonou .

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Editors and Affiliations

  1. Fac. Medicina e Chirurgia, Università di Napoli, Via Sergio Pansini 5, Napoli, 80131, Italy

    Lucio Annunziato

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Misonou, H., Trimmer, J.S. (2009). The Diverse Roles of K + Channels in Brain Ischemia . In: Annunziato, L. (eds) New Strategies in Stroke Intervention. Contemporary Neuroscience. Humana Press. https://doi.org/10.1007/978-1-60761-280-3_12

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