Diarrhea pp 61-79 | Cite as

Inflammatory Bowel Disease

  • Steven Bernick
  • Sunanda Kane
Part of the Clinical Gastroenterology book series (CG)


In summary, diarrhea is a frequent complaint in patients with IBD, with a complex pathophysiologic basis. In any patient presenting with a new inflammatory diarrhea, a wide variety of etiologies must be considered, including a new diagnosis of UC or CD. In patients with pre-existing IBD, the prudent clinician must consider not only a potential exacerbation of their documented disease but also a number of other potential confounding conditions. A focused but thorough medical history, physical examination, laboratory evaluation, and imaging studies may be useful. Endoscopic examination of the upper or the lower digestive tracts may be necessary in the majority of patients. There are a number of antidiarrheal therapies that may be used for symptomatic control in these patients; however the treatment of the underlying disease is the primary goal.

Key Words

Inflammatory bowel disease Crohn’s disease Ulcerative colitis CARD15 NOD2 Clostridium difficile Yersinia enterocolitica Escherichia coli 0157:H7 • TNF-α (alpha) 5-Aminosalicylate 5-ASA Irritable pouch syndrome Small bowel bacterial overgrowth Extraintestinal manifestations of IBD Video capsule endoscopy Endoscopy Colonoscopy Esophagogastroduodenoscopy Noncaseating granulomas Terminal ileum Mesalamine Sulfasalazine Glucocorticoids Corticosteroids Cyclosporine Methotrexate Infliximab Adalimumab Certolizumab pegol Natalizumab Immunomodulators Probiotic 


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Steven Bernick
    • 1
  • Sunanda Kane
    • 2
  1. 1.Naval HospitalSan DiegoUSA
  2. 2.Division of Gastroenterology and HepatologyMayo Clinic College of MedicineRochesterUSA

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