Diarrhea pp 357-378 | Cite as

Diarrhea Related to Non-neoplastic Endocrine Diseases

  • Ashwani K. Singal
  • Nischita K. Reddy
  • Don W. Powell
Part of the Clinical Gastroenterology book series (CG)


Diarrhea may result from either neoplastic (e.g., gastrinoma, VIPoma, medullary carcinoma of the thyroid) or non-neoplastic dysfunction of the endocrine glands. This chapter deals with diarrhea due to hyper- or hypofunction of the endocrine pancreas, thyroid, adrenal gland, or congenital immune-related disease affecting several endocrine glands. The epidemiology, clinical features, diagnosis, and treatment of the diarrhea of these non-neoplastic endocrine diseases are covered here. Although some of these diarrheal syndromes are rare, some (e.g., diabetic diarrhea and the diarrhea of hyperthyroidism) are common because of the prevalence of the underlying disease.

Key Words

Non-neoplastic endocrinal diarrhea Diabetic diarrhea Celiac disease Diabetes mellitus Sorbitol Bile acid malabsorption Lymphocytic colitis Pancreatic insufficiency Diabetic microangiopathy Autonomic neuropathy Intestinal fluid and electrolyte transport Intestinal motility Bacterial overgrowth Anorectal dysfunction Fecal incontinence Loperamide Clonidine Somatostatin Thyrotoxicosis Steatorrhea Coefficient of fat absorption Ulcerative colitis Propylthiouracil Beta blockers Addison’s disease Autoimmune polyglandular syndrome APS type I APS type II John F Kennedy IPEX Polyendocrinopathy FOXP3 Cyclosporine Tacrolimus Bone marrow transplantation 



No financial or assistance in any other form was received.


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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Ashwani K. Singal
    • 1
  • Nischita K. Reddy
    • 1
  • Don W. Powell
    • 2
  1. 1.Division of Gastroenterology and Hepatology, Department of Internal MedicineUniv. of Texas Medical BranchGalvestonUSA
  2. 2.Division of Gastroenterology and Hepatology, Department of Internal MedicineThe University of Texas Medical BranchGalvestonUSA

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