Key Points
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Hemochromatosis is an iron-overload syndrome that includes a hereditary and an acquired form
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The main cutaneous manifestations are a brownish bronze to slate gray hyperpigmentation due to hemosiderin deposition, hair loss most commonly involving the pubic region, koilonychias, icthyosiform alterations, and generalized pruritus
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Hyperpigmentation is a very important diagnostic sign, as early treatment with phlebotomy and chelating agents improve the prognosis significantly and even reverses the systemic and skin manifestations
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Parodi, A., Rongioletti, F. (2010). Hemochromatosis. In: Smoller, B., Rongioletti, F. (eds) Clinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional and Deposition Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-60761-181-3_11
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DOI: https://doi.org/10.1007/978-1-60761-181-3_11
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