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Stem Cells with No Tissue Specificity

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Biology of Stem Cells and the Molecular Basis of the Stem State

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

In addition to the tissue-specific stem cells, a distinct stem cell class exists, which consists of cells distributed throughout the organism, in a tissue non-specific manner. These cells may be multipotent [such as the mesenchymal stromal cells (MSCs) that give rise to a variety of mesodermal progeny (for example bone, cartilage, and muscle)]. An additional type, of non-tissue-specific stem cells, consists of pluripotent cells, i.e. cells capable of differentiating into derivatives of all germ layers; multipotent adult progenitor cells (MAPCs) are an example of such pluripotent cells. Embryonic stem cells (ESCs) exhibit superior pluripotency. However, these cells are restricted to a very short period during embryogenesis and share more properties with transiently expanding progenitors than with stem cells.

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  1. Department of Molecular Cell Biology, Weizmann Institute of Science, 76 100, Rehovot, Israel

    Dov Zipori

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Zipori, D. (2009). Stem Cells with No Tissue Specificity. In: Biology of Stem Cells and the Molecular Basis of the Stem State. Stem Cell Biology and Regenerative Medicine. Humana Press. https://doi.org/10.1007/978-1-60761-130-1_3

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