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Probiotics and Immunomodulation

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Dietary Components and Immune Function

Part of the book series: Nutrition and Health ((NH))

Key Points

The human gastrointestinal tract harbors a vast ensemble of microbes representing over 500 different species. In a healthy state, a fine balance exists between the populations of health-promoting and potentially harmful bacteria. Gut microflora plays an important role in the development, maturation and functioning of the immune system. Disruptions in the intestinal homeostasis result in increased susceptibility to infectious diseases, cancers and immunoinflammatory disorders. Many factors such as enteric infections, intake of antibiotics and stress could disturb the intestinal microbial homeostasis. Intake of probiotic organisms have been shown to restore/optimize gut microbial ­balance and promote health and well-being. Lactobacilli and bifidobacteria are commonly used as probiotics. Specific strains of probiotics are able to modulate the functioning of the immune ­system in health and disease. Probiotics enhance immune function in healthy individuals, but down-regulate dysfunctional immune responses in subjects suffering from immunoinflammatory disorders such as allergies and inflammatory bowel diseases. Probiotic-induced immune stimulation is associated with increased protection against intestinal and extra-intestinal infections and cancers, and improved efficacy of vaccines. The mechanisms by which probiotics mediate their disparate immunological effects in health and disease are not fully understood.

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Authors and Affiliations

  1. Faculty of Health School of Biomedical and Health Sciences, Engineering and Science, Hopper Lane, Werribee, Victoria, 3030, Australia

    O. N. Donkor

  2. Faculty of Health Engineering and Science, School of Biomedical and Health Sciences, Hopper Lane, Werribee, Victoria, 3030, Australia

    T. Vasiljevic

  3. Department of Primary Industries, 600 Sneydes Road, Werribee, VIC, 3000, Australia

    H. S. Gill (Professor)

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  1. O. N. Donkor
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  2. T. Vasiljevic
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  3. H. S. Gill
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  1. Health Sciences Center, Department of Health Promotion Sciences, University of Arizona, 1295 N. Martin Ave. 1295, Tucson, 85724-5155, USA

    Ronald Ross Watson

  2. Mel & Enid Zuckerman College of, Public Health, University of Arizona, Tucson, 85724-5163, USA

    Sherma Zibadi

  3. Dept. Nutrition & Dietetics, King's College, Stamford St. 150, London, SE1 9NH, United Kingdom

    Victor R. Preedy

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Donkor, O.N., Vasiljevic, T., Gill, H.S. (2010). Probiotics and Immunomodulation. In: Watson, R., Zibadi, S., Preedy, V. (eds) Dietary Components and Immune Function. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-061-8_34

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