Skip to main content

Mushrooms: Immunomodulating Activity and Role in Health Promotion

  • Chapter
  • First Online:

Part of the book series: Nutrition and Health ((NH))

Key Points

Lentinula edodes, Grifola frondosa, Pleurotus cornucopiae, Pholiota nameko, and many other kinds of edible mushrooms have shown their potent and unique immunomodulating activities. It has mainly been recognized that their activities result from the action of their polysaccharides or polysaccharide–protein complexes. The polysaccharides appear to stimulate the human immune response and to be effective in preventing immunodeficiency diseases via activation of cytokine networks. In this chapter, these properties of the immunomodulating polysaccharides from L. edodes, G. frondosa, P. nameko, P. cornucopiae, and others are described.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Wasser SP, Nevo E, Sokolov D, Reshetnikov S, Timor-Tismenetsky M (2000) Dietary supplements from medicinal mushrooms: diversity of types and variety of regulations. Int J Med Mushrooms 2:1–19

    Article  CAS  Google Scholar 

  2. Wasser SP, Weis AL (1999) Medicinal properties of substances occurring in higher Basidiomycetes mushrooms: current perspectives. Int J Med Mushrooms 1:31–62

    Article  CAS  Google Scholar 

  3. Zaidman BZ, Yassin M, Mahajna J, Wasser SP (2005) Medicinal mushroom modulators of molecular targets as cancer therapeutics. Appl Microbiol Biotechnol 67:453–468

    Article  PubMed  CAS  Google Scholar 

  4. Lull C, Wichers HJ, Savelkoul HFJ (2005) Antiinflammatory and immunomodulating properties of fungal metabolites. Mediat Inflamm 2:63–80

    Article  Google Scholar 

  5. Ikekawa T, Uehara N, Maeda Y, Nakanishi M, Fukuoka F (1969) Antitumor activity of aqueous extracts of edible mushrooms. Cancer Res 29:734–735

    PubMed  CAS  Google Scholar 

  6. Chihara G, Maeda Y, Hamuro J, Sasaki T, Fukuoka F (1969) Inhibition of mouse Sarcoma 180 by polysaccharides from Lentinus edodes (Berk.) sing. Nature 222:687–688

    Article  PubMed  CAS  Google Scholar 

  7. Ohno N, Iino K, Takeyama T, Suzuki I, Sato K, Oikawa S, Miyazaki T, Yadomae T (1985) Structural characterization and antitumor activity of the extracts from matted mycelium of cultured Grifola frondosa. Chem Pharm Bull 33:3395–3401

    Article  PubMed  CAS  Google Scholar 

  8. Nanba H, Hamaguchi A, Kuroda H (1987) The chemical structure of an antitumor polysaccharide in fruit bodies of Grifola frondosa (Maitake). Chem Pharm Bull 35:1162–1168

    Article  PubMed  CAS  Google Scholar 

  9. Liu F, Ooi VEC, Fung MC (1999) Analysis of immunomodulating cytokine mRNAs in the mouse induced by mushroom polysaccharides. Life Sci 64:1005–1011

    Article  PubMed  CAS  Google Scholar 

  10. Okazaki M, Adachi Y, Ohno N, Yadomae T (1995) Structure-activity relationship of (1 → 3)-β-d-glucans in the induction of cytokine production from macrophages, in vitro. Biol Pharm Bull 18:1320–1327

    Article  PubMed  CAS  Google Scholar 

  11. Sakurai T, Ohno N, Yadomae T (1994) Changes in immune mediators in mouse lung produced by administration of soluble (1 → 3)-β-d-glucan. Biol Pharm Bull 17:617–622

    Article  PubMed  CAS  Google Scholar 

  12. Mosmann TR, Coffman RL (1989) TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7:145–173

    Article  PubMed  CAS  Google Scholar 

  13. Jin M, Jung HJ, Choi JJ, Jeon H, Oh JH, Kim B, Shin SS, Lee JK, Yoon K, Kim S (2003) Activation of selective transcription factors and cytokines by water-soluble extract from Lentinus lepideus. Exp Bio Med 228:749–758

    CAS  Google Scholar 

  14. Mizuno M, Minato K, Tsuchida H (1996) Preparation and specificity of antibodies to an anti-tumor β-glucan, lentinan. Biochem Mol Biol Int 39:679–685

    Google Scholar 

  15. Mizuno M, Yamakawa A, Minato K, Kawakami S, Tatsuoka S, Tsuchida H (1999) Preparation of antibody against antitumor β-glucan in Grifola frondosa and its application. Food Sci Technol Res 5:398–401

    Article  CAS  Google Scholar 

  16. Nanba H, Kuroda H (1987) Antitumor mechanisms of orally administered shiitake fruit bodies. Chem Pharm Bull 35:2459–2464

    Article  PubMed  CAS  Google Scholar 

  17. Minato K, Mizuno M, Kawakami S, Tatsuoka S, Denpo Y, Tokimoto K, Tsuchida H (2001) Changes in immunomodulating activities and content of antitumor polysaccharides during the growth of two medicinal mushrooms, Lentinus edodes (Berk.) Sing. and Grifola frondosa (Dicks.: Fr) S. F. Gray. Int J Med Mushrooms 3:1–7

    Article  CAS  Google Scholar 

  18. Kodama N, Komuta K, Sakai N, Nanba H (2002) Effects of D-fraction, a polysaccharide from Grifola frondosa on tumor growth involve activation of NK cells. Biol Pharm Bull 25:1647–1650

    Article  PubMed  CAS  Google Scholar 

  19. Minato K, Abe C (2008) An immunomodulating action of a polysaccharide fraction from an edible mushroom, Pleurotus cornucopiae var. citrinopileatus. J Clin Biochem Nutr 43:359–362

    Google Scholar 

  20. Minato K (2008) A polysaccharide fraction from an edible mushroom, Pleurotus cornucopiae var. citrinopileatus stimulates an immunomodulating action of murine macrophage, RAW264, on TNF-α and NO productions in vitro. Int J Med Mushrooms 10:235–244

    Article  CAS  Google Scholar 

  21. Minato K, Kasahara S (2006) Immunomodulating action of edible mushrooms, Pleurotus cornucopiae var. citrinopileatus and Pholiota nameko. 8th International Mycological Congress, Medimond S. r. l., Italy, pp 219–224

    Google Scholar 

  22. Sorimachi K, Akimoto K, Ikehara Y, Inafuku K, Okubo A, Yamazaki S (2001) Secretion of TNF-α, IL-8 and nitric oxide by macrophages activated with Agaricus blazei Murill fractions in vitro. Cell Struct Funct 26:103–108

    Article  PubMed  CAS  Google Scholar 

  23. Nanba H, Kuroda H (1988) Potentiation of host-mediated antitumor activity by orally administered mushroom (Agaricus bispora) fruit bodies. Chem Pharm Bull 36:1437–1444

    Article  PubMed  CAS  Google Scholar 

  24. Mizuno M, Shiomi Y, Minato K, Kawakami S, Ashida H, Tsuchida H (2000) Fucogalactan isolated from Sarcodon aspratus elicites release of tumor necrosis factor-α and nitric oxide from murine macrophages. Immunopharmacology 46:113–121

    Article  PubMed  CAS  Google Scholar 

  25. Kawakami S, Minato K, Imamura T, Aizono Y, Mizuno M (2003) Stimulation of TNF-α and NO production from murine macrophage by water-soluble polysaccharides from Isaria japonica. In: Shahidi F, Ho CT, Watanabe S, Osawa T (eds) Food factors in health promotion and disease prevention: ACS Symposium Series 851. American Chemical Society, Washington, DC, pp 152–162

    Chapter  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ken-ichiro Minato PHD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Minato, Ki. (2010). Mushrooms: Immunomodulating Activity and Role in Health Promotion. In: Watson, R., Zibadi, S., Preedy, V. (eds) Dietary Components and Immune Function. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-061-8_28

Download citation

  • DOI: https://doi.org/10.1007/978-1-60761-061-8_28

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-060-1

  • Online ISBN: 978-1-60761-061-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics