Soft-tissue sarcomas are rare malignant soft-tissue tumors that arise from mesodermal tissue, most commonly from the connective, muscle, adipose, neural, and vascular tissues. Approximately two new cases of soft-tissue sarcoma are diagnosed in Japan annually per 100,000 population. They are very heterogeneous, and more than 50 different types have been described. They can be managed through multidisciplinary care provided by surgeons, medical oncologists, and radiation oncologists.
Soft-tissue sarcoma CT scan MRI PET Chemotherapy Radiation Liposarcoma
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Yang JC, Chang AE, Baker AR, et al. Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol. 1998;16:197–203.PubMedGoogle Scholar
Pisters PW, Harrison LB, Leung DH, Woodruff JM, Casper ES, Brennan MF. Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma. J Clin Oncol. 1996;14:859–68.PubMedGoogle Scholar
Gilbert NF, Cannon CP, Lin PP, Lewis VO. Soft-tissue sarcoma. J Am Acad Orthop Surg. 2009;17:40–7.PubMedGoogle Scholar
Conrad III EU. Multimodality management of malignant soft-tissue tumors. In: Menedenz LR, editor. Orthopaedic knowledge update: musculoskeletal tumors. Rosemont, IL: American Academy of Orthopaedic Surgeons; 2002. p. 255–9.Google Scholar
Zagars GK, Ballo MT, Pisters PW, Pollock RE, Patek SR, Benjamin RS. Surgical margins and reresection in the management of patients with soft tissue sarcoma using conservative surgery and radiation therapy. Cancer. 2003;97:2544–53.PubMedCrossRefGoogle Scholar
Davis AM, O’Sullivan B, Turcotte R, et al. Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in extremity soft tissue sarcoma. Radiother Oncol. 2005;75:48–53.PubMedCrossRefGoogle Scholar
Billingsley KG, Burt ME, Jara E, et al. Pulmonary metastases from soft tissue sarcoma: Analysis of patterns of diseases and postmetastasis survival. Ann Surg. 1999;229:602–10.PubMedCrossRefGoogle Scholar
Fong Y, Coit DG, Woodruff JM, Brennan MF. Lymph node metastasis from soft tissue sarcoma in adults: Analysis of data from a prospective database of 1772 sarcoma patients. Ann Surg. 1993;217:72–7.PubMedCrossRefGoogle Scholar
van de Luijtgaarden AC, de Rooy JW, de Geus-Oei LF, van der Graaf WT, Oyen WJ. Promises and challenges of positron emission tomography for assessment of sarcoma in daily clinical practice. Cancer Imaging. 2008;8(Suppl A):S61–8.PubMedCrossRefGoogle Scholar